A 26-year-old man comes to your office for an examination because of tremors, spasticity, and drooling. He has headaches and fatigue. On physical examination, he is very slightly icteric, the liver is not palpable, and no spider angiomata are present, but he has resting and intention tremors and spasticity. Slit-lamp examination reveals a yellow-brown ring in the limbus of the cornea. Laboratory tests show elevated AST and ALT and a ceruloplasmin level of 7 mg/dL (normal 20 -35 mg/dL). 1- The diagnosis is a. Hemochromatosis b. Gaucher’s disease c. Biliary cirrhosis d. Wilson’s disease e. Type III glycogen storage disease 2- (yellow-brown ring in the limbus of the cornea) what is the name of this sign? 3- Lab Studies may show Anemia. What is the type of it? What is the mechanism that led to the development of this Anemia ?
Can be willson´s disease. The sign is called Keiser-Fleischer ring. Anemia is due to acute liver failure which leads to hemolytic anemia.
1. D. Wilson's Disease, an inherited disorder of copper metabolism, its characterized by deposition of copper in the liver, brain and other places. its caused by excesive absorption of copper in small intestiness and decreased excretion of copper by liver. 2. Keiser-Fleischer ring, it is formed by the deposition of copper in the Descemet membrane in the limbus of the cornea 3. Haemolytic Anemia, it occurs as a consequence of oxidative damage to the erythrocytes by the higher copper concentration
1- The diagnosis is Wilson`s disease 2- This sign is named kaiser fleshier ring. 3-Type of anaemia is Hemolytic anaemia due to increase copper cause oxidatoion of erthrocytes.
