free-downloads CSE Video

Saline vs. Mannitol for Elevated Intracranial Tension

Discussion in 'Emergency Medicine' started by Egyptian Doctor, Mar 22, 2011.

  1. Egyptian Doctor

    Egyptian Doctor  Moderator Verified Doctor

    Joined:
    Mar 21, 2011
    Messages:
    9,345
    Likes Received:
    3,206
    Trophy Points:
    16,075
    Gender:
    Male
    Country:
    Egypt

    Mannitol is standard treatment for suspected elevated intracranial pressure (ICP), but it has been implicated in undesirable reductions in mean arterial blood pressure. Researchers performed a meta-analysis of five unblinded randomized trials that compared equiosmolar doses of mannitol and hypertonic saline in a combined total of 112 adult patients with 184 quantitatively documented episodes of elevated ICP. None of the five trials individually identified statistically significant differences between the two agents.

    Combining data from the five trials resulted in slight superiority of hypertonic saline over mannitol (relative risk for ICP reduction, 1.16). The difference in magnitude of ICP reduction with the two agents was not clinically significant.

    Comment: This small meta-analysis of unblinded studies of patients with mixed etiologies of elevated intracranial pressure does not provide sufficient evidence to change therapy from mannitol to hypertonic saline.
     

    Add Reply
  2. Hendra Gandhi

    Hendra Gandhi Moderator

    Joined:
    Mar 23, 2011
    Messages:
    315
    Likes Received:
    15
    Trophy Points:
    695
    Occupation:
    General Practitioner
    Country:
    Indonesia
    so mannitol still the one good for ICP reduction..
     

  3. Egyptian Doctor

    Egyptian Doctor  Moderator Verified Doctor

    Joined:
    Mar 21, 2011
    Messages:
    9,345
    Likes Received:
    3,206
    Trophy Points:
    16,075
    Gender:
    Male
    Country:
    Egypt
    Yes i think so
     

  4. g12321

    g12321 Super Moderator

    Joined:
    Mar 23, 2011
    Messages:
    132
    Likes Received:
    31
    Trophy Points:
    445
    Country:
    Mauritius
    I think so, well that's what I wrote for my paper today for that question.
     

  5. Clothes

    Clothes Well-Known Member

    Joined:
    May 15, 2011
    Messages:
    1
    Likes Received:
    0
    Trophy Points:
    205
    Occupation:
    ??????????
    Country:
    Russian Federation
    Big thanks

    Big thanks
     

  6. Dr.jebsy

    Dr.jebsy Active member

    Joined:
    Feb 21, 2015
    Messages:
    12
    Likes Received:
    1
    Trophy Points:
    30
    Gender:
    Female
    Country:
    United States
    thanks
     

Share This Page