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Stem Cells May Be Key To Understanding The Origins Of Colon

Discussion in 'Oncology' started by Egyptian Doctor, Mar 22, 2011.

  1. Egyptian Doctor

    Egyptian Doctor  Moderator Verified Doctor

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    Scientists at IRB Barcelona report new data in support of link between stem cells and cancer, opening door to new tools for diagnosis and treatment.

    Colorectal cancer cells trigger a set of genes similar to those found in intestinal stem cells, scientists at the Institute for Research in Biomedicine (IRB Barcelona) have found. The team of researchers, led by ICREA researcher Eduard Batlle, propose that patients with colorectal cancer undergo genetic tests of their intestinal epithelium in order to predict a higher risk of relapse. The results of the study, published online this week in Cell Stem Cell, offer new possibilities for diagnosing and treating the disease.

    Colon cancer is the second cause of death by cancer worldwide. Current treatment for the disease normally involves a combination of surgery and chemotherapy. Most patients who are treated successfully go into remission, but nearly 40% relapse within months or years, when the cancer returns or metastasizes. "This shows us that there are cells within the tumour that regenerate the disease," says Batlle, "but we still know very little about the biological reasons why."

    Cancer's "hard core"

    The study conducted by Anna Merlos-Su
     

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