Summary. A 40-year old woman presented with a productive cough for 3 months that was worsening with yellow and sometimes blood-stained sputum; there was also shortness of breath on exertion and weight loss of 3 kilograms. She had fever on and off and night sweats for 1 month. There was no chest pain or ankle swelling. On examination she looks wasted; slightly breathless, blood pressure 110/70 mm Hg, pulse rate 100/min (regular), temperature 38,5Â° C, respiratory rate 20/min. JVP is not raised. The mouth showed oral thrush; no KS. In the lungs there was reduced chest expansion, with dullness on percussion and on auscultation reduced breath sounds with reduced VR and VF on the right hemithorax. The trachea and apex beat were both displaced to the left. On abdominal examination the liver was enlarged by 3 cm; no palpable spleen, no masses, no shifting dullness. No oedema. Questions. 1. What’s your differential diagnosis? 2. What investigations should be done?