A Nationwide Population‐Based Longitudinal Study Mapping Psychiatric Disorders During Lifetime In Si

Siblings to patients with a diagnosis of bipolar disorder were compared with the general population with respect to the rates and cumulative incidences of psychiatric disorders during their lifetime. A total of 13,923 unaffected siblings to 19,955 patients with bipolar disorder and 278,460 unaffected control individuals from the general population matched by year of birth and gender were included in this Danish nationwide population‐based longitudinal register linkage study; these participants were followed-up for 22 years from 1995 to 2017. They noted that rates of “any psychiatric disorder” were consistently increased by around two‐fold throughout lifespan among siblings vs control individuals; however, a bimodal age distribution was observed of hazard ratios of bipolar disorder, unipolar disorder and use of alcohol or psychoactive drugs, with the greatest hazard ratios up to age 20 and above 60 years of age. Cumulative incidences from age 15 years of any psychiatric disorder was 44.2% at age 80 years for siblings vs 27.% for control individuals; for bipolar disorder, those same figures were 8.7% for siblings compared with 1.6% for control individuals.

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