Changes In Dietary Inflammatory Index Patterns With Weight Loss In Women: A Randomized Controlled Tr

A randomized controlled trial was designed to evaluate the variations in dietary inflammatory index patterns with weight loss in women. Researchers randomized a sum of 438 overweight/obese, healthy, postmenopausal women to a caloric-restriction diet (goal: 10% weight-loss), aerobic-exercise (225 min/week moderate-to-vigorous activity), combined diet+exercise, or control. Dietary inflammatory index (DII) and energy-adjusted (E-DII) scores were derived from food frequency questionnaires (FFQ) and could be estimated for 365 participants with complete FFQs at baseline and 12 months. They examined variations from baseline to 12 months in E-DII scores in the intervention arms vs controls applying generalized estimating equations, adjusted for confounders. The data illustrated that a behavior change of low-calorie, low-fat diet significantly decreases dietary inflammatory potential, modulating biomarkers that are correlated with tumorigenesis, such as VEGF, but not C-reactive protein or IL6.

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