Introduction Carpal tunnel syndrome (CTS) is a prevalent condition that affects the hand and wrist, leading to pain, numbness, and functional impairment. This condition is often the result of a combination of factors that increase pressure on the median nerve and tendons in the carpal tunnel. For many patients, carpal tunnel release (CTR) surgery offers a significant improvement in quality of life by relieving the symptoms of CTS. This article provides an exhaustive overview of CTR, including its indications, surgical techniques, postoperative care, potential complications, prognosis, and more. Indications for Carpal Tunnel Release Carpal tunnel release is typically indicated for patients who have persistent symptoms of CTS that do not improve with conservative treatment measures such as wrist splinting, medications, and steroid injections. Indications for surgery include: Significant pain and numbness in the hand affecting daily activities Weakness or atrophy of the thumb muscles Neurological findings on electromyography (EMG) and nerve conduction studies Lack of response to non-surgical therapies over a period of several months Preoperative Evaluation Before proceeding with surgery, a thorough evaluation is essential to confirm the diagnosis and rule out other conditions that may mimic CTS. This evaluation includes: Clinical history and physical examination Electrophysiological tests to assess the function of the median nerve Imaging studies like ultrasound or MRI if there is an atypical presentation or to evaluate the anatomy of the carpal tunnel Contraindications Absolute contraindications to CTR include active infections at the surgery site or systemic infections. Relative contraindications may include uncontrolled diabetes mellitus, which can affect wound healing and nerve recovery. Surgical Techniques and Steps The main goal of CTR surgery is to relieve pressure on the median nerve by cutting the transverse carpal ligament. There are two main surgical techniques: Open Carpal Tunnel Release: This traditional technique involves a 2 to 4 cm incision in the palm. The surgeon then visually identifies and divides the transverse carpal ligament. Endoscopic Carpal Tunnel Release: This minimally invasive technique uses a small incision and an endoscope to visualize and cut the ligament. This method may lead to quicker functional recovery and less postoperative discomfort. Postoperative Care Postoperative management includes: Wound care to prevent infection Mild analgesics to manage pain Hand therapy to restore movement and strength Night splinting if needed Patients typically return to light activities within a few days and may resume full activity levels within 4 to 6 weeks. Possible Complications While CTR is generally safe, complications can occur: Infection Nerve damage Scarring and persistent pain Complex regional pain syndrome Different Techniques and Recent Advances Recent advances in CTR include: Ultrasound-guided percutaneous carpal tunnel release Robot-assisted carpal tunnel release Use of collagenase injections as a non-surgical treatment alternative Prognosis and Outcome The majority of patients experience significant symptom relief following CTR, with improved hand function and quality of life. However, some patients may experience residual symptoms, especially if there was severe nerve damage before surgery. Alternative Options Before considering surgery, alternative treatment options include: Physical therapy Occupational therapy Non-steroidal anti-inflammatory drugs (NSAIDs) Corticosteroid injections Average Cost The cost of CTR can vary significantly depending on geographical location, surgical technique, and healthcare facility. Typically, the cost ranges from $2,000 to $5,000 in the United States. Conclusion Carpal tunnel release is a highly effective surgical option for patients with persistent carpal tunnel syndrome symptoms. With advancements in surgical techniques and a thorough understanding of the condition, surgeons can achieve excellent outcomes for their patients.