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DDx

Discussion in 'Spot Diagnosis' started by J.P.C. Peper, Aug 13, 2012.

  1. J.P.C. Peper

    J.P.C. Peper Bronze Member

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    What’s your diagnosis, based on this bone marrow smear?

    I’ll post the correct answer in a couple of days!

    DDx.JPG
     

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    J.P.C. Peper, Aug 13, 2012
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  2. J.P.C. Peper

    J.P.C. Peper Bronze Member

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    If anyone has an idea, there’s still time.

    I’ll post the correct answer in another three days.
     

    J.P.C. Peper, Aug 16, 2012
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  3. lakmalDJ

    lakmalDJ Famous Member

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    these are Tear-drop cells aka dacrocytes,pepper..suggestive of Chronic myelofibrosis
     

    lakmalDJ, Aug 16, 2012
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  4. J.P.C. Peper

    J.P.C. Peper Bronze Member

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    Correct answer:

    Yes, these are tear drop cells, which are seen in myelofibrosis.

    In this disease, the proliferation of abnormal stem cells leeds to fibrosis, by activation of fibroblasts. This results in pancytopenia (causing infection, anemia, bleeding), splenomegaly, bone pain and fatigue.
     

    J.P.C. Peper, Aug 19, 2012
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