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Diet Reverses Diabetes And Lowers Blood Pressure

Discussion in 'Hospital' started by The Good Doctor, Jun 1, 2021.

  1. The Good Doctor

    The Good Doctor Golden Member

    Aug 12, 2020
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    New research has shown that if you lose substantial weight and maintain that to manage your type 2 diabetes, you can also effectively control your high blood pressure.

    Many in the study cut down or even stopped their anti-hypertensive medication.

    A weight management programme, developed by researchers at the Universities of Glasgow and Newcastle for the Diabetes UK-funded DIabetes REmission Clinical Trial (DIRECT), has proved effective at lowering blood pressure and reducing the need for anti-hypertensive medications, as well as bringing remission of type 2 diabetes.

    The programme involves an initial 12 weeks on a nutritionally complete formula diet (low calorie soups and shakes) which will induce weight loss of over 15 kg (over 2 stones) if followed fully. Diabetes and blood pressure drugs were stopped at the start, and only re-started if blood sugar or blood pressure rose.


    The weight loss phase is followed by support to choose foods and eat wisely for weight loss maintenance. Maintaining the 15 kg weight loss allowed 8 out of 10 people to become free from type 2 diabetes, without the need for diabetes medications for at least 2 years.

    This study, published in the journal Diabetologia, looked at 143 people who started the diet programme, with more than half (78 people) on tablets for high blood pressure at the start (and 44 on two or more drugs). The researchers found that, overall, average blood pressure fell steadily as people lost weight. And blood pressure remained lower after the formula diet period finished, and then at 12 and at 24 months.

    Professor Roy Taylor, from Newcastle University, said: “Guidelines encourage doctors to start tablets but there have been few demonstrations of how tablets can be stopped.

    “My patients, like so many, do not like swallowing multiple tablets, and this study is important as we can now reassure them that stopping blood pressure tablets is not only safe but also good for their health. We’ve shown that when substantial weight loss is achieved and maintained, patients can effectively manage both their blood pressure and type 2 diabetes without drugs.”

    Results in lowering blood pressure

    For those not previously treated for high blood pressure, blood pressures fell sharply from week one. For those who had stopped their blood pressure tablets, blood pressure still fell, although more slowly. Just over a quarter (28%) needed to reintroduce a blood pressure tablet during the formula diet period. However, researchers also found that the same proportion of participants (28%) were able to remain off their medications for at least two years.

    Prof. Mike Lean, from the University of Glasgow, said: “We wanted to evaluate the safety and efficacy of withdrawing blood pressure medication when beginning our specially-designed weight-loss programme for type 2 diabetes, and we are really pleased with the results.

    “Our study shows that, in addition to possible remission from type 2 diabetes, there are other very important health benefits, as weight loss is a very effective treatment for hypertension and its associated serious health risks.

    “Currently, over half of all the 4.5 million people with type 2 diabetes in UK also require tablets for hypertension, to reduce serious vascular complications. Being overweight is the main cause, and losing weight can bring a remission from hypertension for many, as well as a remission of diabetes. Withdrawing blood pressure medications is safe, provided people lost weight and blood pressure was checked regularly, in case tablets needed to be reintroduced.

    “The DiRECT trial was done entirely in primary care. The evidence shows that GPs can safely offer an evidence-based intensive weight management intervention, aiming for substantial weight loss and remission of type 2 diabetes. The study further highlights the links between diet, weight, type 2 diabetes and hypertension, and how long-term support to maintain weight loss is vital.”

    Dr. Elizabeth Robertson, Director of Research at Diabetes UK which funded the study, said: “These important results show that the Diabetes UK-funded DiRECT low-calorie, weight management programme not only helps some people put their type 2 diabetes into remission, but can also lower blood pressure, allowing some people to safely stop taking their blood pressure medication.

    “We’re delighted to see more evidence of the life-changing impact of the DiRECT programme on people’s health. This makes us even more determined to make sure as many people as possible have access to type 2 diabetes remission services.”

    The study'Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT)' is published in Diabetologia.

    Kathleen’s story

    With tests showing that she had developed Type 2 diabetes, Kathleen Brough, was recruited onto the DiRECT study at Newcastle University in 2016.

    Already on hypertension medication, the 68-year-old from Prudhoe, Northumberland, successfully lost weight, reversing her Type 2 diabetes. She explains:

    “Sticking to 800 calories a day was really tough for the first few days then I got into the routine of measuring everything out precisely. Cooking for my husband in the evening was the hardest part and often I’d have to take myself off – for a bath or something to distract myself.

    “The nurses at my GP surgery were really supportive, talking me through everything as well as weighing me and taking my measurements.

    “I lost over 2 stones in 3 months – at my lowest dropping to 9 stone 3lbs. My family were really encouraging but the reaction of people who hadn’t seen me for a while was the funniest, as many would worry that something was wrong with me as they could see I had lost so much weight. I’d say to them that I felt better than I had done in a long time!

    “I didn’t have to start medication for my diabetes and I’ve cut my hypertension medication. It’s the best thing I’ve ever done for my health and for my family.”


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