Effectiveness Of Incentivised Adherence And Abstinence Monitoring In Buprenorphine Maintenance: A

This study was undertaken to investigate the clinical efficacy of a novel incentivized medication adherence and abstinence monitoring protocol in buprenorphine (BUP) maintenance to enable contingent access to increasing take‐home medication supplies. Researches conducted a two‐arm, single‐center, pragmatic, randomized controlled trial of outpatient BUP maintenance, with during‐treatment follow‐ups at 4 weeks, 8 weeks, 12 weeks, and 16 weeks. For the analysis, 171 were enrolled and 141 were randomly assigned to incentivized adherence and abstinence monitoring (70 [49.6%]) and to treatment‐as‐usual (71 [50.4%] out of 182 screened individuals. It was shown that buprenorphine maintenance with incentivized therapeutic drug monitoring to enable contingent access to increasing take‐home medication supplies increased abstinence from opioids vs buprenorphine maintenance treatment‐as‐usual, but it did not seem to increase treatment retention.

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