centered image

centered image

Engineered Cartilage to Reconstruct Damaged Noses

Discussion in 'Plastic Surgery' started by Hala, Apr 17, 2014.

  1. Hala

    Hala Golden Member Verified Doctor

    Joined:
    Oct 17, 2013
    Messages:
    1,685
    Likes Received:
    619
    Trophy Points:
    4,075
    Gender:
    Female
    Location:
    Cairo
    Practicing medicine in:
    Egypt

    A team led by Ivan Martin from University of Basel in Switzerland recruited 5 volunteers, ages 76 to 88, who suffered defects to their nose after surgery to remove non-melanoma skin cancer tumors. This cancer is the most common on the nose because of its exposure to the sun -- specifically on the alar wings (the part that lifeguards in old movies covered with white, opaque sunblock). To remove the tumor completely, surgeons often have to cut away parts of the cartilage. With the standard technique, grafts for reconstruction are taken from other cartilaginous parts of the body, such as the ears or the ribs.


    To see if there was another way to reconstruct the nose without an additional surgery, the team extracted cartilage cells (called chondrocytes) from the patient’s own nasal septum, harvested during their tumor biopsy sample. Over the course of a month, these cells were multiplied, expanded, and finally, seeded onto a collagen membrane, which acts like a scaffold. These were cultured in a serum for an additional two weeks, and then the resulting engineered cartilage grafts (with dimensions 25 mm × 25 mm × 2 mm) where shaped according to the patient’s defect. These were then implanted after tumor excision, and covered with skin from their forehead.



    Half a year later, the reconstructed tissues showed “fibromuscular” fatty structures, which are typical for healthy alar lobules. After a year, all the patients were satisfied with the aesthetics and functioning of their reconstructed nose; no side effects have been reported. The same engineered grafts are being tested now in knees.



    “Now that we have demonstrated this is safe and feasible, we can use [this technique] for more complicated clinical needs,” Martin tells Boston Globe. While scientists are slowly gaining more expertise in making body parts, it could take another couple of decades before the process becomes mainstream. “It’s not a trivial thing to engineer a functional tissue,” he adds.



    [​IMG]




    Source
     

    Add Reply

Share This Page

<