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Examination Of Androgenetic Alopecia With Serum Biomarkers

Discussion in 'General Discussion' started by The Good Doctor, Oct 10, 2020.

  1. The Good Doctor

    The Good Doctor Golden Member

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    The present study was conducted to assess microinflammation, perifollicular fibrosis, and oxidative stress in androgenetic alopecia (AGA) cases, some serum biomarker levels. Researchers collected serum samples from patients (n = 58) and control (n = 30) groups referring to Atatürk Training and Investigation Hospital Dermatology Outpatient clinic. They assessed NF‐κB, TNF‐α, TGF‐β1, thioredoxin, nitric oxide, TOS, TAS, and thiol-disulfide homeostasis (native thiol, total thiol, disulfide) in serum samples. It was shown that AGA androgens lead to oxidative stress by elevating free oxygen radicals, which accelerates hair loss by causing microinflammation and fibrosis. For the development of new and effective treatment methods, the recognition of the effect of androgens and associated factors on the hair follicle cycle is very essential.

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