Food Anthocyanins Decrease Concentrations Of TNF-α In Older Adults With Mild Cognitive Impairment: A

Among 31 older adults with mild cognitive impairment (MCI), researchers examined the impacts of food anthocyanins on microvascular function, 24-hour ambulatory blood pressure (ABP), and inflammatory biomarkers. For this randomized, controlled, double-blind clinical trial, participants drank 250 mL of fruit juice daily for 8 weeks, allocated into three groups: high dose anthocyanins (201 mg), low dose anthocyanins (47 mg), and control. Relative to controls and the low anthocyanins group, participants in the high anthocyanins group had a decrease in serum tumor necrosis factor alpha (TNF-α). Treatment did not modify serum IL-6, IL-1β, C-reactive protein and microvascular function parameters and 24h ABP. In older adults with MCI, a high daily dose of fruit-based anthocyanins for 8 weeks lowered TNF-α concentrations. Other inflammatory biomarkers, microvascular function or blood pressure parameters were not altered by anthocyanins.

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