Frequency, Clinical Features, Inflammatory Cytokines And Genetic Background Of Latent Autoimmune Dia

Researchers conducted this nationwide, multicenter, cross‐sectional study to analyze the frequency, clinical phenotype, inflammatory cytokine levels and genetics of the glutamic acid decarboxylase autoantibody (GADA)‐positive phenotypic youth‐onset type 2 diabetes. Five thousand three hundred twenty-four newly diagnosed patients with phenotypic type 2 diabetes aged ≥ 15 years enlisted in the LADA China study. In 248 patients with youth‐onset type 2 diabetes aged 15‐29 years, GADA was screened. Of the 248 patients, 29 (11.7%) were GADA positive. In youth‐onset type 2 diabetes patients in China, a high GADA positivity was detected. Since latent autoimmune diabetes in youth (LADY) had an increased susceptible HLA genetic load and different cytokine levels compared with type 2 diabetes, it is important to differentiate LADY from phenotypic type 2 diabetes patients.

​

Source