This study was carried out to evaluate whether glycemic index, the glycemic load was associated with cardiovascular disease and mortality. In this study, researchers examined 137,851 participants between the ages of 35 and 70 years living on five continents, with a median follow-up of 9.5 years. Researchers applied country-specific food-frequency questionnaires to ascertain dietary intake and estimated the glycemic index and glycemic load on the basis of the consumption of seven categories of carbohydrate foods. Multivariable Cox frailty models were applied to estimate hazard ratios. A composite of a major cardiovascular event (cardiovascular death, nonfatal myocardial infarction, stroke, and heart failure) or death from any cause was the primary endpoint. This study indicated that a diet with a high glycemic index was correlated with an elevated risk of cardiovascular disease and death. Source
