The Mayo Clinic has taken the top spot on U.S. News & World Report's "Best Hospitals" rankings for the sixth year in a row. For the 2021-2022 edition, the Cleveland Clinic took second place, with UCLA Medical Center coming in third. Johns Hopkins Hospital in Baltimore claimed fourth place, and Massachusetts General Hospital in Boston came in fifth. (The full list of the Top 20 "Honor Roll" is below.) Keck Medical Center of the University of Southern California in Los Angeles fell off the Top 20, and was replaced by Vanderbilt University Medical Center in Nashville. U.S. News & World Report also released rankings for 15 medical specialties, including cancer, cardiology, and orthopedics. MD Anderson Cancer Center in Houston ranked first in cancer, the Cleveland Clinic took the top spot in cardiology, and the Hospital for Special Surgery in New York came in at the top of the orthopedics list. (See Top 10 lists below.) New this year is the inclusion of health equity rankings, according to a press release from U.S. News. While health equity isn't factored into this year's rankings, this information is included alongside them. These measures examine whether patients treated at the hospital reflect the racial and ethnic diversity of the community. "At roughly four out of five hospitals, we found that the community's minority residents were underrepresented among patients receiving services such as joint replacement, cancer surgery and common heart procedures," said Ben Harder, managing editor and chief of health analysis at U.S. News, in a statement. "Against this backdrop, however, we found important exceptions -- hospitals that provide care to a disproportionate share of their community's minority residents," Harder added. "These metrics are just a beginning; we aim to expand on our measurement of health equity in the future." This year's rankings involved more than 4,750 medical centers nationwide; 175 of them were nationally ranked in at least one specialty, while 531 were ranked among the best regional hospitals. 2021-2022 Best Hospitals "Honor Roll" 1. Mayo Clinic, Rochester, Minnesota 2. Cleveland Clinic 3. UCLA Medical Center, Los Angeles 4. Johns Hopkins Hospital, Baltimore 5. Massachusetts General Hospital, Boston 6. Cedars-Sinai Medical Center, Los Angeles 7. NewYork-Presbyterian Hospital-Columbia and Cornell 8. NYU Langone Hospitals, New York 9. UCSF Medical Center, San Francisco 10. Northwestern Memorial Hospital, Chicago 11. University of Michigan Hospitals-Michigan Medicine, Ann Arbor 12. Stanford Health Care-Stanford Hospital, Palo Alto, California 13. Hospitals of the University of Pennsylvania-Penn Presbyterian, Philadelphia 14. Brigham and Women's Hospital, Boston 15. Mayo Clinic-Phoenix 16. Houston Methodist Hospital 17. Barnes-Jewish Hospital, St. Louis (tie) 18. Mount Sinai Hospital, New York (tie) 19. Rush University Medical Center, Chicago 20. Vanderbilt University Medical Center, Nashville 2021-2022 Top 10 Hospitals in Select Specialties Cancer 1. University of Texas MD Anderson Cancer Center, Houston 2. Memorial Sloan Kettering Cancer Center, New York 3. Mayo Clinic, Rochester, Minnesota 4. Dana-Farber/Brigham and Women's Cancer Center, Boston 5. Cleveland Clinic 6. Johns Hopkins Hospital, Baltimore (tie) 7. Northwestern Memorial Hospital, Chicago (tie) 8. UCLA Medical Center, Los Angeles 9. Cedars-Sinai Medical Center, Los Angeles 10. Hospitals of the University of Pennsylvania-Penn Presbyterian, Philadelphia Cardiology & Heart Surgery 1. Cleveland Clinic 2. Mayo Clinic, Rochester, Minnesota 3. Cedars-Sinai Medical Center, Los Angeles 4. NewYork-Presbyterian Hospital-Columbia and Cornell 5. NYU Langone Hospitals, New York 6. Mount Sinai Hospital, New York 7. Massachusetts General Hospital, Boston 8. Stanford Health Care-Stanford Hospital, Palo Alto, California 9. UCLA Medical Center, Los Angeles 10. Brigham and Women's Hospital, Boston Orthopedics 1. Hospital for Special Surgery, New York 2. Mayo Clinic, Rochester, Minnesota 3. Cedars-Sinai Medical Center, Los Angeles 4. NYU Langone Orthopedic Hospital, New York 5. UCLA Medical Center, Los Angeles 6. Rush University Medical Center, Chicago 7. Cleveland Clinic 8. Massachusetts General Hospital, Boston 9. NewYork-Presbyterian Hospital-Columbia and Cornell 10. Rothman Orthopaedics at Thomas Jefferson University Hospitals, Philadelphia Source