After contracting the coronavirus in March, Michael Reagan lost all memory of his 12-day vacation in Paris, even though the trip was just a few weeks earlier. Several weeks after Erica Taylor recovered from her Covid-19 symptoms of nausea and cough, she became confused and forgetful, failing to even recognize her own car, the only Toyota Prius in her apartment complex’s parking lot. Lisa Mizelle, a veteran nurse practitioner at an urgent care clinic who fell ill with the virus in July, finds herself forgetting routine treatments and lab tests, and has to ask colleagues about terminology she used to know automatically. “I leave the room and I can’t remember what the patient just said,” she said, adding that if she hadn’t exhausted her medical leave she’d take more time off. “It scares me to think I’m working,” Ms. Mizelle, 53, said. “I feel like I have dementia.” It’s becoming known as Covid brain fog: troubling cognitive symptoms that can include memory loss, confusion, difficulty focusing, dizziness and grasping for everyday words. Increasingly, Covid survivors say brain fog is impairing their ability to work and function normally. “There are thousands of people who have that,” said Dr. Igor Koralnik, chief of neuro-infectious disease at Northwestern Medicine in Chicago, who has already seen hundreds of survivors at a post-Covid clinic he leads. “The impact on the work force that’s affected is going to be significant. Scientists aren’t sure what causes brain fog, which varies widely and affects even people who became only mildly physically ill from Covid-19 and had no previous medical conditions. Leading theories are that it arises when the body’s immune response to the virus doesn’t shut down or from inflammation in blood vessels leading to the brain. Confusion, delirium and other types of altered mental function, called encephalopathy, have occurred during hospitalization for Covid-19 respiratory problems, and a study found such patients needed longer hospitalizations, had higher mortality rates and often couldn’t manage daily activities right after hospitalization. French report in August on 120 patients who had been hospitalized found that 34 percent had memory loss and 27 percent had concentration problems months later. In a soon-to-be-published survey of 3,930 members of Survivor Corps, a group of people who have connected to discuss life after Covid, over half reported difficulty concentrating or focusing, said Natalie Lambert, an associate research professor at Indiana University School of Medicine, who helped lead the study. It was the fourth most common symptom out of the 101 long-term and short-term physical, neurological and psychological conditions that survivors reported. Memory problems, dizziness or confusion were reported by a third or more respondents. “It is debilitating,” said Rick Sullivan, 60, of Brentwood, Calif., who’s had episodes of brain fog since July after overcoming a several-week bout with Covid-19 breathing problems and body aches. “I become almost catatonic. It feels as though I am under anesthesia.” Wreaking havoc on the job Erica Taylor, a lawyer, has had episodes where her brain feels like “white static.” She couldn’t recognize her car in her apartment complex’s parking lot and had to take a leave from her job. When Ms. Taylor, 31, contracted the virus in mid-June, she thought she’d need only a brief break from working as a lawyer for an Atlanta nonprofit helping low-income tenants. But she became so disoriented that she washed her TV remote with her laundry and had to return a foster dog she’d recently taken in because she couldn’t trust herself to care for a pet. One morning, “everything in my brain was white static,” she said. “I was sitting on the edge of the bed, crying and feeling ‘something’s wrong, I should be asking for help,’ but I couldn’t remember who or what I should be asking. I forgot who I was and where I was.” By July, she thought she’d improved and told her boss she could return. But after another “white static” episode, she messaged him: “I’m scared. I really want to get back to work. But, I keep getting really tired and really confused.” He suggested she rest and heal. She resumed working in early August, but her mind wandered and reading emails was “like reading Greek,” she said. By September, her employer urged a 13-week leave. “They finally landed on ‘You’re going to have to step away,’” said Ms. Taylor, who requested to volunteer for the nonprofit while on leave but was told no. “I’m gutted, to be honest.” Mr. Reagan looks through a book of photographs from his trip to Paris in March. He can’t remember anything about it. Mr. Reagan, 50, who spent five days in and out of hospitals, initially resumed work as a vascular specialist for a company that makes stents and catheters. But finger tremors and seizures, neurological symptoms that sometimes accompany brain fog, meant “there is no way I’m going to go into surgery and teach a doctor how to suture an artery,” he said. In meetings, “I can’t find words,” said Mr. Reagan, who has now taken a leave. “I feel like I sound like an idiot.” Before Ms. Mizelle contracted the virus in July and was hospitalized with pneumonia for five days in August, she’d treat six patients an hour by herself at her clinic in Huntsville, Ala. But recently, she said, “I told our scheduler I can’t work alone because I’m slow in thinking, I’m dizzy, and I just need somebody else there to work with me.” Sometimes in exam rooms, she said, “I’m trying to be slick with the patient so they don’t know, because you don’t want your provider to be in a fog, which is very scary.” She’s forgotten to order cultures for urinary infections, but a lab technician caught it, saying “I’ve got you, Lisa,” Ms. Mizelle said. “As far as I know, I have not made a mistake,” she said, adding that things have recently improved slightly. “I haven’t killed anybody yet.” Searching for answers to a mysterious cause Brain fog’s cause is a mystery partly because symptoms are so varied. “The simplest answer is people still have persistent immune activation after the initial infection subsided,” said Dr. Avindra Nath, chief of infections of the nervous system at the National Institute of Neurological Disorders and Stroke. Inflammation in blood vessels, or cells lining the vessels, may be involved, said Dr. Serena Spudich, chief of neurological infections and global neurology at Yale School of Medicine. Inflammatory molecules, released in effective immune responses, “can also be sort of toxins, particularly to the brain,” she said. Tiny strokes may cause some symptoms, said Dr. Dona Kim Murphey, a neurologist and neuroscientist, who herself has experienced post-Covid neurological issues, including “alien hand syndrome,” in which she felt a “super-bizarre sense of my left hand, like I didn’t understand why it was positioned the way it was and I was really captivated by it.” Other possible causes are autoimmune reactions “when antibodies mistakenly attack nerve cells,” Dr. Spudich said. Symptoms like tingling or numbness can occur when damaged nerves send wrong signals, said Dr. Allison Navis, a neuro-infectious disease specialist at Mount Sinai Health System. Some people with brain fog still experience lung or heart issues, which can exacerbate neurological symptoms. So far, MRI scans haven’t indicated damaged brain areas, neurologists say. Dr. Murphey, scientific director for a brain-wave technology company, who couldn’t summon the word “work” in a recent meeting, said research is crucial so symptoms are taken seriously. “People say in a disparaging way ‘It’s all in their head,’” she said. “In this case it is literally in our heads, and it is very real.” Forgetting Paris, and how to say toothbrush This summer, Mr. Reagan, the vascular medicine specialist, turned the stove on to cook eggs and then absent-mindedly left to walk the dog, Wolff-Parkinson-White, named after a cardiac arrhythmia. Returning to discover a dangerously hot empty pan, he panicked and hasn’t cooked since. He’s forgotten this past Christmas, New Year’s and the Paris vacation in March that he arranged for his partner Mustafa Al Niama’s 40th birthday. “I look at all my pictures of Paris, trying to remember,” he said, showing a selfie of the couple at the Mona Lisa in the Louvre. “We went and saw a Madonna concert, we went to the Eiffel Tower, we went to the Catacombs. And I remember nothing, nothing at all.” Mr. Sullivan navigates a spectrum of cognitive speed bumps. In the mildest state, which he calls “fluffy,” his head feels heavy. In the middling phase, “fuzzy,” he said, “I become angry when people talk to me because it hurts my brain to try and pay attention.” Most severe is “fog,” when “I cannot function” and “I sit and stare, unmotivated to move, my mind racing.” Even slight mental or physical exertion can trigger his fog, and Mr. Sullivan, laid off before the pandemic from a senior position with a photography company, said many days he could manage only two responsibilities: “Clean the kitty litter and pick up dog poop.” Even that was anxiety-provoking. “To me, it was a series of 15 or 16 tasks,” he said. “Oh, my God, I have to find a bag to put the litter in, then I have to take the lid off.” Julia Donahue, 61, of Somers, N.Y., struggles to speak in fluid sentences, painful because she’s long enjoyed playing Abigail Adams in historical programs. “Now, Abigail is just a bunch of dresses in my closet,” she said. “I wouldn’t be able to give a 45-minute address.” Recently, she couldn’t even recall “toothbrush,” saying to a friend “‘You know, the thing that makes your teeth clean.’” Experts advise people with brain fog to see doctors to rule out other medical conditions and treat remaining physical symptoms. Ms. Mizelle, Mr. Reagan, Ms. Taylor and others are consulting cardiologists and other specialists, along with neurologists. Doctors don’t know whether symptoms will improve or evaporate with time. Some patients are devising workarounds or makeshift recovery exercises. Mr. Reagan, who’s also lost his sense of direction, follows a therapist’s suggestion to walk to random locations near his home in Lower Manhattan. Recently, he chose the New York Stock Exchange, several blocks away. He wrote down directions and read them repeatedly before setting out with his partner and their dog. At the first corner, his mind faltered. “Left?” he asked Mr. Al Niama, who informed him they should turn right. In mid-September, Mr. Sullivan thought the worst was over, but at the grocery store with his wife, he developed “full-blown fog,” gripped the cart and “wandered around the store like a zombie,” he said. Days later, he was lifting three-pound dumbbells — nothing compared with his pre-Covid 65-pound routine — when “Bam, the fog hit me,” he recalled, realizing, “I’m not over this.” Then he broke down, sobbing. Source
