Perspective > Medscape Diabetes & Endocrinology Levothyroxine Dosing: Morning, Night, or In Between? Angela M. Leung, MD, MSc Levothyroxine, the synthetic form of thyroxine, is routinely used as the primary form of thyroid hormone replacement in the management of hypothyroidism, a condition that affects up to 7% of the general population.[calcium carbonate,[aluminum hydroxide,[sucralfate,[cholestyramine,[colesevelam,[raloxifene,[orlistat,[Helicobacter pylori–related gastritis, atrophic gastritis, or celiac disease, a higher dose of levothyroxine may be needed to overcome these malabsorptive states.