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Lymphatic filariasis

Discussion in 'Parasitology' started by medicine 299, Jul 18, 2014.

  1. medicine 299

    medicine 299 Young Member

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    Lymphatic filariasis
    Infection with the filarial worms Wuchereria bancrofti and Brugia malayi
    is associated with clinical outcomes ranging from subclinical infection to
    hydrocele and elephantiasis.
    The infection is widespread in tropical Africa, the North African coast,
    coastal areas of Asia, Indonesia and northern Australia, the South Pacific
    islands, the West Indies and also in North and South America.
    Pathology
    Several factors contribute to the pathogenesis of lymphatic filariasis.
    1- Toxins released by the adult worm cause lymphangiectasia; this
    dilatation of the lymphatic vessels leads to lymphatic dysfunction
    and the chronic clinical manifestations of lymphatic filariasis,
    lymphoedema and hydrocele.
    2- Death of the adult worm results in acute filarial
    lymphangitis.Lymphatic obstruction persists after death of the
    adult worm.
    3- Secondary bacterial infections cause tissue destruction.
    4- The host response to microfilariae is central to the pathogenesis of
    tropical pulmonary eosinophilia.
     

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