Mapping Of Pathological Change In Chronic Fatigue Syndrome Using The Ratio Of T1- And T2-Weighted MR

In this study, the T1w/T2w signal intensity values were mapped in the whole brain for forty-five myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) patients who met Fukuda criteria and twenty-seven healthy controls and applied both region- and voxel-based quantification. Researchers also conducted interaction-with-group regressions with clinical measures to investigate for T1w/T2w relationships that are abnormal in ME/CFS at the population level. This study’s findings illustrate that the T1w/T2w approach is very sensitive and exhibits increases in myelin and/or iron in WM and basal ganglia in ME/CFS.

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