Metabolically Healthy Obesity, Transition To Unhealthy Metabolic Status, And Vascular Disease In Chi

In the present study, the researchers sought to investigate the relationship of metabolic health status and its transition with risks of subtypes of vascular disease across body mass index (BMI) categories. The China Kadoorie Biobank was carried out during June 25 2004, to July 15, 2008, in 5 urban (Harbin, Qingdao, Suzhou, Liuzhou, and Haikou) and 5 rural (Henan, Gansu, Sichuan, Zhejiang, and Hunan) regions across China. Participants were classified into BMI categories: normal weight (BMI 18.5–23.9 kg/m²), overweight (BMI 24.0–27.9 kg/m²), and obese (BMI ≥ 28 kg/m²). Among Chinese adults, metabolically healthy obesity people have increased risks of major vascular events. Independent of major metabolic factors, obesity remains a risk factor for cardiovascular disease. Data further show that metabolic health is a transient state for a large proportion of Chinese adults, with the highest vascular risk for those who remain metabolically unhealthy overweight or obesity.

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