For the first time, scientists have come up with a precise atomic level explanation for why glulisine- a commonly used medication to treat diabetes- is faster acting than insulin. The findings, published today in Scientific Reports, could have benefits for diabetes patients in ensuring that a more improved insulin can be developed for future treatment. The study was carried out by experts from the Universities of Nottingham and Manchester and Imperial College London, along with the Diamond Light Source - the UK's national synchrotron science facility. Glulisine is a synthetic rapid-acting synthetic insulin developed by Sanofi-Aventis - with a trade name of Apidra. It is used to improve blood sugar control in adults and children with diabetes. In this new study, scientists set out to establish the exact structure of gluisine, and how this structure might affect the way in which it behaves physiologically. The team aimed to establish, by examining the structure, what fundamental role gluisine plays in diabetes management. These findings could potentially lead to an improved synthetic insulin for patients, with fewer side effects. Dr. Gary Adams Associate Professor and Reader in Applied Diabetes Health at the University of Nottingham, and Lead author of the study, said: “For the first time, our research provides novel, structural information on a clinically relevant synthetic insulin, glulisine, which is an important treatment for those patients presenting with diabetes. “This information sheds light on the dissociation of glulisine and can explain its fast dissociation to dimers and monomers and thereby its function as a rapid-acting insulin. This new information may lead to a better understanding of the pharmacokinetic and pharmacodynamic behaviour of glulisine and, in turn, might assist in improving its formulation and reducing side effects of this drug.” Source
