Oncological Safety And Functional Outcomes Of Testosterone Replacement Therapy In Symptomatic Adult-

The present study was conducted to assess the safety and functional impacts in patients after definitive surgical treatment with robotic-assisted radical prostatectomy (RARP). Researchers conducted a retrospective analysis including a total of 1,303 patients who had undergone RARP during the years 2006–2019. They distinguished men with symptoms of andropause and low serum testosterone who received testosterone replacement therapy (TRT) post-RARP; then the cohort was classified into two groups accordingly for comparison. The primary endpoint was the biochemical recurrence. Functional outcomes were secondary outcomes. Univariable and multivariable logistic regression were applied to assess predictors of biochemical recurrence (BCR), including the effect of TRT on BCR. The data imply that in prostate cancer patients post-RARP, TRT, in well-selected, closely followed, symptomatic men post-RARP is an oncologically safe and functionally effective treatment.

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