Optimal Levofloxacin Dosing Regimens In Critically Ill Patients With Acute Kidney Injury Receiving

Researchers sought to ascertain suitable dosing of levofloxacin among critically ill patients undergoing continuous renal replacement therapy (CRRT). They defined optimal dosing regimens as the dose achieved target PTA (probability of target attainment) at least 90% of the virtual patients. It was found that at least 90% of PTA for Gram-negative infection with Pseudomonas aeruginosa was not achieved by any of the conventional, FDA approved regimens at MIC (minimum inhibitory concentration) of 2 mg/L. For Gram-positive infections, experts noted the adequacy of a levofloxacin 750 mg q 24 h for achieving PTA target of ~90% at the MIC of 2 mg/L for Streptococcus pneumoniae. Based on these findings, experts concluded that owing to suboptimal efficacy, levofloxacin cannot be advised as an empiric monotherapy for serious Gram-negative infections in patients undergoing CRRT.

​

Read the full article on Journal of Critical Care.

Source