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PITX2 Knockout Induces Key Findings of Electrical Remodeling as Seen in Persistent Atrial Fibrillati

Discussion in 'Cardiology' started by Valery1957, Feb 14, 2023.

  1. Valery1957

    Valery1957 Famous Member

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    BACKGROUND: Electrical remodeling in human persistent atrial fibrillation is believed to result from rapid electrical activation of the atria, but underlying genetic causes may contribute. Indeed, common gene variants in an enhancer region close to PITX2 (paired-like homeodomain transcription factor 2) are strongly associated with atrial fibrillation, but the mechanism behind this association remains unknown. This study evaluated the consequences of PITX2 deletion (PITX2-/- ) in human induced pluripotent stem cell-derived atrial cardiomyocytes.
     

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