Security Review Results It has been shown that propylhexedrine in a dose of 100 to 300 mg can have a psychoactive effect similar to amphetamine, including psychosis (including with paranoia, hallucinations, delusions and agitation). Also, propylhexedrine can lead to tachycardia, arterial hypertension, arrhythmia, dilated pupils, vasoconstriction. The development of propylhexedrine began in the 1940s. The drug was not considered a drug and was positioned as a safe means. However, recently 2 young patients were admitted to the Dartmouth-Hitchcock Medical Center (USA) with propylhexedrine-associated toxicity. The authors of the report performed a literary review of studies published from 1970 to 2019. During this period, 28 clinical cases of propylhexedrine toxicity have been described. The first case (acute psychosis) was described in 1970 in New Zealand. In 2011, one patient died after using a combination of propylhexedrine with mitrazhin (the active component of kratom). How do addicts get propylhexedrine? Users open the lid, dip a cotton swab. A cotton swab can then be cut and swallowed. A cotton swab can also be placed in an acidic liquid such as soda or lemon juice for an extended period to extract the drug. The resulting extract is then injected into a vein, smoked or inhaled. The most dangerous delivery method is intravenous injection. The authors of the report emphasize that anyone can go and buy a relatively small amount of the drug (widespread availability + low price), open the inhaler, and inside it there are about 250 mg of propylhexedrine, which is enough to cause psychoactive effects. The authors fear that this drug may become more prevalent. Source: American Academy of Addiction Psychiatry (AAAP) 30th Annual Meeting: Abstract 5. Presented December 8, 2019.
