This is a highly unusual place for the life-threatening infection to take hold. An illustration of methicillin-resistant Staphylococcus aureus, or MRSA, which is one cause of "flesh-eating" infections. (Image: © Shutterstock) A woman developed an infection with "flesh-eating" bacteria in her eye sockets — a highly unusual place for the life-threatening infection to take hold, according to a new case report. The 58-year-old woman went to the emergency room after she developed eye pain and swelling that had become progressively worse over five days, according to the report, published Nov. 7 in The Journal of Emergency Medicine. An eye exam showed she had severe swelling around both her eye sockets as well as pus discharging from her eyes. A woman developed severe swelling around both her eye sockets, as well as pus discharging from her eyes, as a result of an infection with "flesh-eating" bacteria. (Image credit: Reprinted with permission of Elsevier (2019).) At first, it appeared that she could have cellulitis, a bacterial infection of the skin and underlying tissues. But when the patient's symptoms worsened even after she received antibiotics, doctors suspected she could have a more serious condition — necrotizing fasciitis, an infection that destroys skin and muscle tissue and spreads quickly in the body. These "flesh-eating" infections are rare overall, and necrotizing fasciitis of the eye socket is rarer still, with only a handful of cases ever reported in the medical literature, the authors wrote. A tissue sample taken from the women's eye socket — known medically as the orbit — confirmed that she had orbital necrotizing fasciitis. Study co-author Dr. Ryan Walsh, an assistant professor in the Department of Emergency Medicine at Vanderbilt University Medical Center in Tennessee, said he had never seen a case like this before. It's "probably a once in a career case," Walsh told Live Science. Although rare, people can get necrotizing fasciitis when bacteria enter the body through breaks in the skin, including cuts and scrapes, burns and surgical wounds, according to the Centers for Disease Control and Prevention (CDC). Necrotizing fasciitis can occur anywhere in the body, but is most commonly seen in the limbs or the abdominal wall, according to the University of Iowa. The rich blood supply in the face and eyes generally helps reduce the risk of flesh-eating infections in these areas, Walsh said. (Flesh-eating infections tend to thrive in low-oxygen environments with reduced blood supply, Walsh added.) When cases of orbital necrotizing fasciitis do occur, they are most often seen after surgery or trauma in people with conditions that make them more susceptible to infection, such as diabetes. In the current case, it's unclear how the woman acquired the infection, but she was taking a medication for rheumatoid arthritis that weakened her immune system, which increased her risk of severe infections, Walsh said. Several types of bacteria can cause necrotizing fasciitis. In the woman's case, tests showed she was infected with methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes. But regardless of the cause, the condition is usually very serious, even fatal. Up to one-third of patients with necrotizing fasciitis die from their infection, according to the CDC. The fatality rate from orbital necrotizing fasciitis is about 12%, the authors said. The woman underwent repeated surgeries to remove damaged or dead tissue from the area, and received antibiotics to treat the specific strains of bacteria she was infected with. After 13 days in the hospital, she was well enough to go home. She was released in stable condition, Walsh said, and to his knowledge she does not have vision loss. Source
