Hi so I have wondered of the pharmacological reason behind the very complete inhibition of or almost complete reduction of the craving of the psychoactives present in tobacco. This is a typical phenomena felt almost consistently among users. Though despite this widespread action, I've not, to this date, seen a relevant neuropharmacological reasoning for it. I initially, due to the perceived effects on myself, attributed it to a potential antagonistic action at the nicotinic AchCh site. Due to it feeling like this. Unable to confirm this suspicion I remembered an article which described the attenuation of tobacco craving by mental stimulation. That is, being mentally involved in tasks demanding of brain processes reduces the cravings for tobacco by participants. But then this is in complete conflict with the tendency of other amphetamines in increasing the desire to smoke. Such as racemic or dextroamphetamine... So, does anybody have an answer to this. I am not hopeful but shit I've searched the internet over and still this makes no sense as to the cause of it. Good day.
IDK the exact mechanism also I didn't find much evidence based information about the nicotin-psychostimulants relationship But psychostimulants inhibits MAOIs thus mainting dopamine, serotonin and other reward and euphoric neurotransmitters for longer time Nicotine does the same but directly not by activating MOAIs,, so there is the synergestic effect,, nicotine increases dopamine and amphetamines inhibit its breakdown So the brain calls for more dopamine through cravings,, I found many studies proves that theory * amphetamines increase smoke craving * but none of them explains why,, just theories
