Risk‐Adapted Starting Age Of Breast Cancer Screening In Women With A Family History Of Ovarian Or Ot

A nationwide cohort study was designed to explore the starting age of breast cancer screening in women with a family history of ovarian or other cancers. Researchers included 5,099,172 Swedish women born after 1931 (follow‐up, 1958‐2015) using Swedish family cancer data sets. They estimated the relative risk of breast cancer for women with a family history of discordant cancer in 1 first‐degree relative. The highest risk of breast cancer was observed for those with a family history of ovarian cancer among women younger than 50 years. Risk of breast cancer associated with a family history at other cancer sites in these women ranged from 1.08‐fold for prostate cancer to 1.18‐fold for liver cancer. Women with 1 first‐degree relative with ovarian cancer reached the threshold risk for screening at the age of 46 years when breast cancer screening was recommended for the general population to start at 50 years of age. Women with a family history of other discordant cancers did not reach the risk thresholds for screening at younger ages. According to the findings, familial relationships with breast cancer were seen with many cancers, but women with a family history of these cancers (other than ovarian cancer) did not reach risk thresholds for screening at younger ages.

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