Scientists Think They've Finally Found The Mechanism Behind Grey Hair And Baldness

As we get older, many of us struggle with the harsh reality of our hair turning grey or falling out. But despite how common these problems are, scientists have struggled to identify their underlying biological cause, which means that we've been stuck using quick fixes such as hair dye and toupees to mask the problem.

Now, scientists have finally identified the specific cells that cause hair to grow and develop pigment in mice - a big step towards developing a treatment for grey hair and baldness.

The researchers actually stumbled upon these 'hair progenitor cells' by accident while researching a rare genetic disorder that causes tumours to grow on nerves, called Neurofibromatosis Type 1.

"Although this project was started in an effort to understand how certain kinds of tumours form, we ended up learning why hair turns grey and discovering the identity of the cell that directly gives rise to hair," said lead researcher Lu Lefrom the University of Texas Southwestern Medical Centre.

"With this knowledge, we hope in the future to create a topical compound or to safely deliver the necessary gene to hair follicles to correct these cosmetic problems."

Researchers already knew that skin stem cells contained in the bulge at the bottom of hair follicles were involved in hair growth, but they weren't quite sure what it was made these skin cells turn into hair cells. So they couldn't begin to find a way to target them or stimulate their growth.

But while researching tumour formation on nerve cells, they discovered the protein that sets these cells apart.

Called KROX20, the protein is more commonly associated with nerve development. But in hair follicles in mice the team discovered it switches on in skin cells that will go on to become the hair shaft that makes hair grow.

This protein then causes these cells to produce a protein called stem cell factor(SCF), and when both of these molecules are expressed in a cell, they move up the hair bulb, interact with pigment-producing melanocyte cells, and grow into healthy, coloured hairs.

But if one or the other is missing, the process goes wrong. When the team deleted the KROX20-producing cells, they found that no hair grew and mice became bald.

When they deleted the SCF gene in these hair-progenitor cells, the animal's hair turned white.

To be clear, this research has only been conducted in mice so far. While we have a lot of biological similarities with mice, the study needs to be repeated in humans before we can get too excited.

But Le and his team are already working on a project that will look for KROX20 and SCF in people with greying and thinning hair, in an attempt to work out whether it's associated with male pattern baldness in humans.

The hope is that it might not only teach us about why our hair changes as we get older, but also ageing in general. And the fact that the research could potentially lead to treatments that will help us look younger for longer doesn't hurt either.

The research has been published in Genes & Development.



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