This study was sought to examine the airway microbiome in chronic obstructive pulmonary disease (COPD), bronchiectasis, and bronchiectasis‐COPD overlap (BCO). Researchers carried out to search PubMed, Google Scholar, EMBASE, and Web of Science. They included all studies involving human microbiomes, published in the English language, and using the search terms “COPD”, “Chronic Obstructive Pulmonary Disease”, “Bronchiectasis”, “BCO” or “Bronchiectasis and COPD overlap”, AND “microbiome”, “mycobiome” or “metagenomics”. The results of this study demonstrate that the use of next-generation sequencing has revolutionized our detection and understanding of the airway microbiome in chronic respiratory diseases such as COPD and bronchiectasis. As per the findings, targeted amplicon sequencing indicates important relationships between the respiratory microbiome and disease outcome while metagenomics may elucidate functional pathways. How best to apply this information into patient care, evaluating and treatment nevertheless remain challenging and required future trials. Source
