The Role Of EMMPRIN/CD147 In Regulating Angiogenesis In Patients With Psoriatic Arthritis

The present study was sought to evaluate the role of EMMPRIN/CD147 in regulating angiogenesis in patients with psoriatic arthritis. In this study, the serum levels of several pro- and anti-angiogenic factors were assessed in 62 psoriatic arthritis (PsA) patients with active disease, 39 PsA patients in remission, 33 active rheumatoid arthritis patients, and 33 healthy controls. Researchers applied an in a vitro co-culture system of fibroblast and monocytic-like cell lines, to assess how their interactions affect the secretion of angiogenic factors and angiogenesis promoting abilities using scratch and tube formation assays. It was shown that in PsA, CD147 plays a role in mediating angiogenesis, and the therapeutic possibilities of neutralizing it merit future study.

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