Time Courses Of Urinary Creatinine Excretion, Measured Creatinine Clearance And Estimated Glomerular

Given that a link of baseline urinary creatinine excretion (UCE) with ICU outcome has been reported but no information has been acquired about its time course, therefore researchers analyzed patients with an ICU-stay ≥ 30d without acute kidney injury stage 3 in order to ascertain alterations in UCE, plasma creatinine, measured creatinine clearance and estimated glomerular filtration (eGFR) in this patient population. Experts applied the Cockcroft-Gault, MDRD (modification of diet in renal disease) and CKD-EPI (chronic kidney disease epidemiology collaboration) equations. Findings revealed reduction of UCE by ≥1%/d over 1 month of ICU stay, this may correspond to an equal decrease in muscle mass. Among survivors, non-survivors, males and females, these rates of UCE reduction were shown to be similar, highlighting the intransigent nature of this process. A progressive increase in estimates of eGFR during ICU stay was observed, in contrast to recorded creatinine clearance.

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