Introduction Health Economics and Outcomes Research (HEOR) is a critical field within healthcare, bridging the gap between clinical research and healthcare decision-making. HEOR firms play a pivotal role in assessing the value of healthcare interventions, guiding policy decisions, and optimizing healthcare expenditures. This article delves into the top 25 HEOR firms globally, highlighting their contributions, methodologies, and impact on healthcare systems. 1. IQVIA IQVIA is a global leader in HEOR, providing advanced analytics, technology solutions, and contract research services. Their comprehensive approach includes real-world evidence generation, economic modeling, and patient-reported outcomes research. IQVIA's vast data resources and innovative methodologies make it a go-to partner for healthcare stakeholders. 2. Optum Optum is a part of UnitedHealth Group, specializing in HEOR services that focus on improving healthcare delivery and outcomes. Their expertise in data analytics, clinical insights, and cost management strategies helps clients navigate complex healthcare landscapes and achieve sustainable results. 3. ICON plc ICON plc offers a wide range of HEOR services, including health technology assessments, economic evaluations, and patient-centered outcomes research. With a global presence and a robust team of experts, ICON plc supports pharmaceutical companies, payers, and regulatory bodies in making informed healthcare decisions. 4. Pharmerit International Pharmerit International, now part of OPEN Health, is renowned for its evidence synthesis, economic modeling, and real-world data analysis. Their interdisciplinary team works closely with clients to develop customized HEOR strategies that demonstrate the value of healthcare interventions. 5. RTI Health Solutions RTI Health Solutions provides HEOR services across the drug development lifecycle. Their offerings include health economics, epidemiology, patient preference studies, and outcomes research. RTI's rigorous methodologies and scientific expertise ensure high-quality, impactful research. 6. Syneos Health Syneos Health integrates clinical and commercial solutions, offering HEOR services that span from clinical development to market access. Their comprehensive approach includes economic modeling, real-world evidence generation, and value communication, helping clients optimize their healthcare products' market potential. 7. Evidera Evidera, part of PPD, provides evidence-based solutions in HEOR, real-world evidence, and market access. Their services include systematic literature reviews, economic modeling, and patient-reported outcomes research. Evidera's scientific rigor and strategic insights drive effective healthcare decision-making. 8. Adelphi Values Adelphi Values specializes in patient-centered outcomes research, health economics, and strategic market access. Their expertise in developing patient-reported outcome measures and conducting qualitative research ensures that patient perspectives are integrated into healthcare evaluations. 9. Analysis Group Analysis Group offers a broad range of HEOR services, including economic evaluations, epidemiological studies, and policy analysis. Their multidisciplinary team collaborates with clients to generate robust evidence that supports health policy and clinical practice decisions. 10. Health Advances Health Advances provides strategic consulting services in HEOR, focusing on market access, pricing, and reimbursement strategies. Their in-depth industry knowledge and analytical capabilities help clients navigate the complexities of healthcare markets and achieve commercial success. 11. Pharmerit – an OPEN Health Company Pharmerit, now integrated with OPEN Health, excels in health economics, patient-centered outcomes research, and real-world evidence generation. Their collaborative approach and scientific expertise enable them to deliver high-impact HEOR solutions. 12. Xcenda Xcenda, a part of AmerisourceBergen, offers HEOR services that include value proposition development, health economics modeling, and outcomes research. Their strategic insights and evidence-based approach help clients demonstrate the value of their healthcare innovations. 13. Precision HEOR Precision HEOR, part of Precision Medicine Group, focuses on health economics, outcomes research, and payer engagement strategies. Their customized solutions and innovative methodologies support clients in optimizing market access and reimbursement outcomes. 14. Covance Market Access Covance Market Access, a division of Labcorp, provides HEOR services that include economic modeling, patient-reported outcomes research, and real-world evidence generation. Their comprehensive solutions help clients navigate the regulatory and market access landscape. 15. ICON Commercialisation & Outcomes ICON's Commercialisation & Outcomes division specializes in HEOR, market access, and real-world evidence. Their integrated approach and extensive industry experience enable them to deliver impactful solutions that support healthcare decision-making. 16. IMS Health IMS Health, now part of IQVIA, offers a wide range of HEOR services, including economic modeling, outcomes research, and market access strategies. Their extensive data resources and analytical capabilities make them a trusted partner in healthcare research. 17. PAREXEL International PAREXEL International provides HEOR services that include health technology assessments, economic evaluations, and patient-reported outcomes research. Their scientific expertise and strategic insights help clients demonstrate the value of their healthcare interventions. 18. Medpace Medpace offers HEOR services that focus on economic modeling, patient-centered outcomes research, and real-world evidence generation. Their integrated approach and scientific rigor ensure high-quality, impactful research. 19. Kantar Health Kantar Health, part of Kantar, provides HEOR services that include health economics, outcomes research, and patient-reported outcomes. Their extensive data resources and analytical capabilities support clients in making evidence-based healthcare decisions. 20. Deloitte Health Economics & Outcomes Research Deloitte offers HEOR services that include economic modeling, health technology assessments, and policy analysis. Their multidisciplinary team and strategic insights help clients navigate the complexities of healthcare markets and achieve sustainable results. 21. Charles River Associates Charles River Associates provides HEOR services that include economic evaluations, outcomes research, and policy analysis. Their scientific expertise and strategic insights drive effective healthcare decision-making. 22. Abt Associates Abt Associates offers HEOR services that focus on economic modeling, health technology assessments, and real-world evidence generation. Their comprehensive solutions and scientific rigor ensure high-quality, impactful research. 23. Veranex Veranex provides integrated HEOR services that include economic modeling, patient-reported outcomes research, and real-world evidence generation. Their customized solutions and innovative methodologies support clients in optimizing market access and reimbursement outcomes. 24. TriNetX TriNetX offers HEOR services that include real-world evidence generation, economic evaluations, and outcomes research. Their extensive data resources and analytical capabilities support clients in making evidence-based healthcare decisions. 25. Oxford Outcomes Oxford Outcomes, part of ICON plc, specializes in health economics, outcomes research, and patient-centered outcomes. Their scientific rigor and strategic insights drive effective healthcare decision-making and market access strategies. Conclusion The field of Health Economics and Outcomes Research (HEOR) is integral to optimizing healthcare systems, improving patient outcomes, and ensuring the efficient allocation of healthcare resources. The top 25 HEOR firms highlighted in this article are at the forefront of this critical work, providing evidence-based solutions that guide healthcare decision-making and policy. Their innovative methodologies, comprehensive data resources, and strategic insights make them invaluable partners in the healthcare landscape.