Conclusion According to the results of a large meta-analysis, vitamin D supplements do not have a prophylactic effect on fractures and falls and do not have a clinically significant effect on bone mineral density. Do not distinguish between low and high doses of vitamin. Thus, vitamin D supplements do not play a big role in maintaining or improving musculoskeletal health. Source: Mark J Bolland, Andrew Gray, Alison Avenell. Lancet Diabetes & Endocrinology. Published October 04, 2018.