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A New Way Engineered To Inhibit Allergic Reactions Without Side Effects

Discussion in 'Biomedical Engineering' started by Egyptian Doctor, Oct 19, 2011.

  1. Egyptian Doctor

    Egyptian Doctor  Moderator Verified Doctor

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    Researchers from the University of Notre Dame have announced a breakthrough
    approach to allergy treatment that inhibits food allergies, drug allergies, and asthmatic
    reactions without suppressing a sufferer's entire immunological system.


    The therapy centers on a special molecule the researchers designed, a
    heterobivalent ligand (HBL), which when introduced into a person's bloodstream
    can, in essence, out-compete allergens like egg or peanut proteins in their race
    to attach to mast cells, a type of white blood cell that is the source of type-I
    hypersensitivity (that is, allergy).

    "Unlike most current treatments,
    this approach prevents allergic reactions from occurring in the first place"
    says Basar Bilgicer, assistant professor of Chemical and Biomolecular
    Engineering and Chemistry and Biochemistry and principal investigator in Notre
    Dame's Advanced Diagnostics & Therapeutics initiative.

    Michael
    Handlogten, lead scientist on the paper and a graduate student in Dr. Bilgicer's
    group, explained that among the various chemical functionalities he analyzed to
    be used as the scaffold HBL synthesis, ethylene glycol, an FDA-approved
    molecule, proved to be the most promising.

    Mast cells are part the human
    body's defense against parasites (such as tapeworms), and when working normally they are
    attracted to, attach to, and annihilate these pathogens. But type-I
    hypersensitivity occurs when the cells react to non-threatening substances. More
    common allergies are due to ambient stimulants, and an allergic response may
    range from a mild itch to life-threatening anaphylactic shock.

    Tanyel Kiziltepe, a
    research professor in Advanced Diagnostics & Therapeutics, adds that
    "anaphylaxis can be caused by certain food allergens, insect stings, antibiotics, and some medicines, and we believe
    HBL has a very high potential to be developed as a preventative medication".


    While many medicines treat allergies by weakening a person's entire
    immune system, this approach only disrupts the process whereby white blood cells
    bond with allergens in the first place.

    "It also does not leave patients
    open to an increased risk for infections or the development of cancers," explains
    Bilgicer. "HBLs may be most useful in situations where it's not possible to
    speak to or gauge someone's sensitivity."

    "For example, in an emergency,
    on a battlefield, or in a remote location, doctors may not be able to ask a
    patient about an allergy before administering penicillin. An engineered HBL
    could be given along with the medicine and perhaps prevent a deadly reaction
    from occurring."

    In a normal allergic reaction, allergens bind to a
    white blood cell, or "mast" cell, and cause the release of inflammatory
    molecules. Researchers at Notre Dame have shown how non-allergenic molecules,
    known as heterobivalent ligands, can be designed to attach to mast cells first,
    preventing the allergic reaction in the first place.

    Source : A New Way Engineered To Inhibit Allergic Reactions Without Side Effects
     

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