Discussion in 'Spot Diagnosis' started by Egyptian Doctor, Nov 18, 2012.
What is your medical diagnosis ?
m.Cooley talassemia maior
Beta Thallasemia / Thalassemia major, ''hair appearance'' is due to chronic haemolytic anamemias (due to hyperplasia of erythroid lineage in the bone marrow ). The cranial vaults space widens as there is a constant attempt to obtain more space for erythropoiesis within the bone marrow - the hyperplasia. The is also trabecular destrucion thickening of the remaining trabeculae - all of these features give the characteristic appearances.
Differentail includes - Thalassemia, Sickle Cell Anemia and Hereditary Spherocytosis (All can give the calssic "hair on end" x-ray pattern)
skull x-ray with "hair on end" pattern---> Cooley's anemia
Answer : CHA Mostly Thalassemia
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