Discussion in 'Spot Diagnosis' started by J.P.C. Peper, Jun 16, 2012.
What's your diagnosis?
I'll post the correct answer in about three days!
Warfarin Necrosis maybe...
Coumarine induced skin necrosis
coumarine necrosis of the mammary gland
Yes, it's warfarin induced skin necrosis.
Clearly a serious complication of medication use; there is still debate about the disease mechanism (paradoxical activation of coagulation vs. direct toxic effect of warfarin vs. some kind of hypersensitivity reaction...).
It usually occurs in obese, middle-aged women. When being confronted by this condition, you should also consider pyoderma gangrenosum and necrotizing fasciitis.
Separate names with a comma.