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Dementia: New WHO Prevention Guidelines Evaluate 12 Risk Factors

Discussion in 'Neurology' started by Mahmoud Abudeif, May 20, 2019.

  1. Mahmoud Abudeif

    Mahmoud Abudeif Golden Member

    Mar 5, 2019
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    Millions of people around the world have a form of dementia, but scientists are still unsure exactly what causes this condition. Nevertheless, newly published prevention guidelines from the World Health Organization evaluate 12 risk factors and offer advice on how to tackle them.

    As many as 50 million people across the world have dementia, an umbrella term for a series of neurodegenerative conditions that cause memory loss. These conditions can become severe enough to impair a person's ability to continue their normal daily activities.

    The most common form of dementia is Alzheimer's disease, which affects 5.8 million people in the United States alone, according to the Alzheimer's Association.

    Even though dementia changes the lives of so many people and their families around the globe, scientists still have not found out exactly what causes the conditions that fall into this category.

    However, the high number of people living with a form of dementia has rendered dementia research a worldwide priority. As a result, we now have a good idea of what risk factors may contribute to its development.

    Some of these factors are lifestyle-related and, as such, modifiable. Therefore, with adequate information, people may be able to learn how to adapt their lifestyle to become healthier and lower their risk of developing various health conditions, including dementia.

    Earlier this week, the World Health Organization (WHO) published a new set of guidelines — downloadable from their website — that seek to advise governments, policymakers, and healthcare providers on how best to tackle dementia prevention.

    Guidelines assess strength of evidence

    These guidelines review existing evidence on the most significant lifestyle-related risk factors for dementia and take each of these factors into account when issuing recommendations for prevention.

    The authors aimed the recommendations at healthcare providers worldwide, but they hope that the guidelines will present a reliable source of information for governmental organizations too, helping them draft better prevention and care policies.

    "In the next 30 years, the number of people with dementia is expected to triple," warns the WHO Director-General Dr. Tedros Adhanom Ghebreyesus.

    "We need to do everything we can to reduce our risk of dementia. The scientific evidence gathered for these guidelines confirm what we have suspected for some time, that what is good for our heart, is also good for our brain," Dr. Ghebreyesus adds.

    In their new guidelines, the WHO evaluate 12 possible risk factors for dementia and offer advice on how to address each of them.

    These possible factors are: low levels of physical activity, smoking, a poor diet, alcohol misuse, insufficient or impaired cognitive reserve (the brain's ability to compensate for neural problems), lack of social activity, unhealthy weight gain, hypertension, diabetes, dyslipidemia (unhealthy cholesterol levels), depression, and hearing loss.

    While the WHO used the guidelines primarily to issue recommendations on how to address each of these potential factors, they also considered whether there is sufficient, strong evidence that tackling these risk factors can help stave off dementia.

    In doing so, they found that there is moderate evidence in support of the notion that being more physically active and following a Mediterranean-style diet can play a protective role against cognitive decline. The same goes for cutting down alcohol consumption.

    Currently, there is insufficient evidence that engaging in more social activities, taking antidepressants, or wearing hearing aids can reduce the risk of dementia. However, the WHO emphasize that being socially involved, adequately treating depression, and managing hearing loss are, nevertheless, important.

    "The existence of potentially modifiable risk factors means that prevention of dementia is possible through a public health approach, including the implementation of key interventions that delay or slow cognitive decline or dementia," the official WHO document maintains, explaining that the organization's action plan for improving global health outcomes lists dementia management as a top priority:

    "The goal of the action plan is to improve the lives of people with dementia, their carers and families, while decreasing the impact of dementia on them as well as on communities and countries."


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  2. Valery1957

    Valery1957 Famous Member

    Jan 10, 2019
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    Diabetes is a Strong Predictor of Dementia
    Along with diabetes and high blood pressure, prehypertension is also a risk factor in increasing the risk of dementia in older patients.
    Publish date: September 4, 2017
    Jan Dyer

    Cardiovascular risk factors, such as diabetes and high blood pressure, increase the risk of dementia. That is not new information, but a long-term funded study by the National Institutes of Health found that not only is diabetes almost as strong a predictor of dementia as the APOE4 gene, but also prehypertension.

    The researchers analyzed data on 15,744 participants aged 45 to 64 years in the Atherosclerosis Risk in Communities (ARIC) study. Over 25 years, the participants were examined 4 times, including being given cognitive tests during all but the first and third exams.

    Stopping Prediabetes Before It Becomes Diabetes‘Unprecedented’ Study Sheds Light on Origins of Diabetes
    “Our results contribute to a growing body of evidence linking midlife vascular health to dementia,” said study leader Rebecca Gottesman, MD, PhD, professor of neurology at Johns Hopkins University in Maryland. “These are modifiable risk factors. Our hope is that by addressing these types of factors early, people can reduce the chances that they will suffer from dementia later in life.”

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