Extent Of Non-Adherence And Non-Persistence In Asthma Patients: Analysis Of A Large Claims Data Set

By discriminating between measurement of non-adherence (NA) in periods of therapy continuation and measurement of non-persistence (NP) in therapy-naïve patients, researchers attempted to evaluate NA and NP to long-acting asthma medications in Germany. Using German claims data for periods of treatment continuation, researchers examined treatment adherence to long-acting asthma medication based on the medication possession ratio and the proportion of days covered. For this analysis, 52,508 asthma patients (mean age: 40.1, 58.4% female) who received at least two long-acting asthma prescriptions within 12 months were included, as were 50,660 treatment-naïve patients in the NP analysis (mean age: 39.7, 58.8% female). The data exhibited that, in Germany, the high levels of treatment NA and NP demonstrate that adherence and persistence to long-acting asthma medication need to be improved. According to the results, 86.7% of patients were concluded to be non-persistent after 12 months, based on a > 90-day gap definition. NP rates ranged from 66.7 to 78.5% when using prescribed daily dosages.

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