Glucose Variability And Risk Of Hepatocellular Carcinoma In Diabetic Patients: A Nationwide Populati

This study was undertaken to investigate the associations between glucose variability (GV) and hepatocellular carcinoma (HCC) in diabetic patients through a nationwide population-based study. Researchers performed a population-based cohort study recruiting a total of 674,178 diabetic individuals participating in more than 3 health examinations within 5 years from the index year (2009-2010) were followed until the end of 2017. They calculated coefficient of variation, standard deviation, variability independent of the mean, and average real variability as GV indices. GV was found to be an independent predictor of HCC, even after adjusting for confounding factors. A linear relationship was observed between the increase in GV and the prevalence of HCC. At high risk of HCC, GV might be helpful for distinguishing diabetic patients.

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