HTCC as a highly effective polymeric inhibitor of 1SARS-CoV-2 and MERS-CoV 23Aleksandra Milewskaa,b,*, Ying Chic, Artur Szczepanskia,b,Emilia Barreto-Durana,Kevin Liud, 4Dan Liud, Xiling Guoc, Yiyue Gec, Jingxin Lic, Lunbiao Cuic, Marek Ochmane, Maciej Urlike,5Sylwia Rodziewicz-Motowidlof, Fengcai Zhuc,h,*, Krzysztof Szczubialkag,*, Maria 6Nowakowskag,*, Krzysztof Pyrca,*78aVirogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian 9University, Gronostajowa 7, 30-387 Krakow, Poland.10bMicrobiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, 11Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.12cNHC Key Lab of Enteric Pathogenic Microbiology, Jiangsu Provincial Centre for Disease13Control & Prevention. 172 Jiangsu Rd., Nanjing, Jiangsu, 210009, PR China14d Nanjing TechboonInstitute of Clinical Medicine. #1003, Tower B of Yangtze Sci. & Tech. 15Innovation Centre, 211 Pubing Rd., Nanjing, Jiangsu, 211800, PR China.16eDepartment of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical 17University of Silesia in Katowice, Silesian Centre for heart diseases, Zabrze, Poland.18f Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdansk, Wita 19Stwosza 63, 80-308 Gdansk, Poland.20gDepartment of Physical Chemistry, Faculty of Chemistry, Jagiellonian University, 21Gronostajowa 2, 30-387, Krakow, Poland.22hCentre for Global Health, Nanjing Medical University. 18 Tianyuan Rd. E., Nanjing, 23Jiangsu, 210009, PR China2425*Corresponding authors26272829303132* Correspondence should be addressed to Krzysztof Pyrc ([email protected])or Maria 33Nowakowska([email protected]) or Krzysztof Szczubialka34([email protected]) or Fengcai Zhu([email protected])or Aleksandra 35Milewska([email protected]).36www: http://virogenetics.info/. 37author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint (which was not peer-reviewed) is the. https://doi.org/10.1101/2020.03.29.014183doi: bioRxiv preprint
