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New Method Isolates Best Brain Stem Cells To Treat Multiple Sclerosis

Discussion in 'Neurology' started by Egyptian Doctor, Oct 18, 2011.

  1. Egyptian Doctor

    Egyptian Doctor Moderator Verified Doctor

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    The prospect of doing human clinical trials with stem cells to treat diseases like multiple sclerosis may be growing closer, say
    scientists at the University at Buffalo and the University at Rochester, who
    have developed a more precise way to isolate stem cells that will make
    myelin.

    Myelin is the crucial fatty material that coats neurons and
    allows them to signal effectively. The inability to make myelin properly is the
    cause of MS as well as rare, fatal, childhood diseases, such as Krabbe's
    disease.

    The research, published online and in the October issue of
    Nature Biotechnology, overcomes an important barrier to the use of stem cells
    from the brain in treating demyelinating diseases.

    Until now, it has been
    difficult to separate out the right progenitor cells the ones that will develop
    into cells that make myelin, explains Fraser Sim, PhD, first and
    co-corresponding author on the paper and assistant professor in the Department
    of Pharmacology and Toxicology in the UB School of Medicine and Biomedical
    Sciences; he did much of the work while he was a researcher at
    Rochester.

    "Characterizing and isolating the exact cells to use in stem
    cell therapy is one key to ultimately having success," said Sim. "You need to
    have the right cells in hand before you can even think about getting to a
    clinical trial to treat people. This is a significant step."

    Sim and
    Rochester graduate student Crystal McClain ran extensive analyses looking at
    gene activity in different types of stem cells, leading to the conclusion that
    stem cells carrying a protein known as CD140a on their surface seemed to be most
    likely to become oligodendrocytes the type of brain cell that makes
    myelin.

    The UB and Rochester scientists then injected the cells into the
    brains of mice that were born without the ability to make myelin. Twelve weeks
    later, the cells had become oligodendrocytes and had coated more than 40 percent
    of the brain's neurons with myelin a four-fold improvement over the team's
    previous results published in Cell Stem Cell and Nature Medicine.

    "These
    cells are our best candidates right now for someday helping patients with M.S.,
    or children with fatal hereditary myelin disorders," said Steven Goldman, MD,
    PhD, co-author, the leader of the team and professor and chair of the Department
    of Neurology at the University of Rochester Medical Center. "These cells migrate
    more effectively throughout the brain, and they myelinate other cells more
    quickly and more efficiently than any other cells assessed thus far. Now we
    finally have a cell type that we think is safe and effective enough to propose
    for clinical trials."

    An eventual treatment of a disease like M.S. might
    involve injecting stem cells to create myelin in the brains of
    patients.

    "Another approach," says Sim, "might involve using certain
    medications to turn on these cells already present in the brains of patients and
    thereby create new myelin. The use of the new techniques described in this work
    will permit us to better understand how human cells behave in the brain and help
    us predict which medications may be successful in the treatment of myelin
    loss."

    The new approach may also be applicable to Krabbe's Disease, Sim
    says, which also involves the breakdown of myelin. Sim, who came to UB in 2009,
    is actively collaborating on related work with researchers at the Hunter James
    Kelly Research Institute, a partnership between UB and the Hunter's Hope
    Foundation and located in UB's New York State Center of Excellence in
    Bioinformatics and Life Sciences.

    [​IMG]

    Source : New Method Isolates Best Brain Stem Cells To Treat MS
     

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    Last edited: Oct 19, 2011

  2. Stephanie Fite

    Stephanie Fite Well-Known Member

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    This is Amazing ! thank you for sharing ;)
     

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  3. Egyptian Doctor

    Egyptian Doctor Moderator Verified Doctor

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    You are welcome Stephanie
     

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