Macrodactyly or Local gigantism may be caused by a heterogeneous group of both congenital and acquired conditions. Congenital Congenital causes include: Klippel Trenaunay Weber syndrome Maffucci syndrome macrodystrophia lipomatosa neurofibromatosis lipoatrophic diabetes. Proteus syndrome, which by one theory accounts for the deformities of the Elephant Man Acquired There are a number of acquired causes of local gigantism. A body part can attain bigger size from causes as common as the following: inflammation, due to trauma or infection tumors like osteoid osteoma, melorheostosis, and lipofibromatous hamartoma Arteriovenous malformations occurring on a limb, before the closure of epiphyses in long bones Elephantiasis, which is quite common in south-east asia due to prevalence of filariasis. Still's disease amyloidosis acromegaly