Type 2 Diabetes And COVID-19-Related Mortality In The Critical Care Setting: A National Cohort Study

In this study, the association between type 2 diabetes and all-cause mortality was explored among adults with coronavirus disease 2019 (COVID-19) in the critical care setting. Researchers designed a nationwide retrospective cohort study in people who admitted to hospital in England with COVID-19 requiring admission to a high dependency unit (HDU) or intensive care unit (ICU) between 1 March 2020 and 27 July 2020. They applied Cox proportional hazards models to calculate 30-day in-hospital all-cause mortality associated with type 2 diabetes, with adjustment for age, gender, ethnicity, obesity, and other major comorbidities (chronic respiratory disease, asthma, chronic heart disease, hypertension, immunosuppression, chronic neurological disease, chronic renal disease, and chronic liver disease). The study enrolled a sum of 19,256 COVID-19–related HDU and ICU admissions in the primary analysis, including 13,809 HDU (mean age 70 years) and 5,447 ICU (mean age 58 years) admissions. The results of this study consider that type 2 diabetes may be an independent prognostic factor for survival in people with severe COVID-19 requiring critical care treatment, and in this setting, the risk increase correlated with type 2 diabetes is greatest in younger people.

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