Binswanger's disease or Subcortical vascular dementia as discribed by Otto Binswanger in 1894 is a form of dementia caused by damage to the white brain matter. Atherosclerosis is the most common cause of Binswanger's disease so it is considered as a particular type of atherosclerosis-related dementia. Binswanger's disease is more common in men between 50 to 70 years old and It is characterized by affection of memory , intellectual function , mood changes and the ability to act or to make decisions. The histologic findings are diffuse, irregular loss of axons and myelin accompanied by gliosis, tissue death. Binswanger's disease has a poor prognosis as there is no cure , also it is considered as one of the most severe types of vascular related dementia , so physicians depends on treating the vascular cause.