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Whats the Diagnosis ?

Discussion in 'Case Studies' started by Xerxles, Apr 24, 2013.

  1. Xerxles

    Xerxles Well-Known Member

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    A 33-year-old woman has experienced low grade fevers, night sweats, and generalized malaise for the past 2 months. On physical examination she has non-tender cervical and supraclavicular lymphadenopathy. A cervical lymph node biopsy is performed. On Microscopy the following is seen.... What your diagnosis ??


    xxx.jpg
     

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    Last edited: Apr 24, 2013

  2. Xerxles

    Xerxles Well-Known Member

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    "Didn't any one recognize the characteristic cells microscopy "
     

  3. Xerxles

    Xerxles Well-Known Member

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    Hint : these are owl eye cells
     

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  4. neo_star

    neo_star Moderator

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    firstly this section is not very popular...ppl r mostly into fast food ( spot diagnosis / pattern recognition ). So ur chances of getting a response increases if u post in the 'fast food section ' P:

    secondly no 2 'lymph node specialists' would ever agree or come to a common diagnosis based on lymph node histology...so u shud not expect the 'masses' to comment, unless of-course it is a clear cut case. Thankfully we have 'immunophenotyping' these days, that doesn't care about the reputation of a pathologist and wud say it the way it is. For instance - lymphocyte predominant ( CD 20 + ) and the nodular lymphocyte predominant ( CD 45 + ) can be hard to distinguish, becos all of them hav some sclerosis and u may end up misdiagnosing....but immunophenotyping will help distinguish.

    now coming to the slides u posted

    slide 1

    HL _ nodular sclerosing.jpg

    slide 2

    mixed cellularity.jpg

    both are 2 different histological subtypes and can't be from the same patient.....even if they are from different lymph nodes.

    why ?
    becos it is the same process that has spread from node to node and hence will have the same identity ( although the reactive cells can be in diff. proportions in diff nodes and also in diff sections from the same node )

    But to ans ur question :: both slides are of patients with 'Hodgkin's Lymphoma', with the first one showing 'Nodular Sclerosing type' histology with 'lacunar type - RS cells' and the second slide showing 'mixed cellularity' with 'classical RS cell'.
     

    Last edited: Apr 26, 2013
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    hussain sadiq Well-Known Member

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    'Hodgkin's Lymphoma
     

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    trio wicaksono Young Member

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    TB, limfoma
     

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    hodgkin's lymphoma
     

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    Tarn Young Member

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    Hodgkin'lymphoma
     

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    Hodgkin s lymphoma
     

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    NinaSlavova Well-Known Member

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    Hodgkin lymphoma
     

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    Hodking's lyphoma
     

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    Es un caso tipico de linfoma de Hodkin.
     

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    Hodgkin linfoma
     

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    Hodgkins Lymphoma
     

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