Human Trials For Artificial Kidney To Begin At The End of 2019, With First Patient Implants In 2020

Ethan Montgonery · Jul 23, 2019

Please contact me as I am more than willing to put my life on the line for the future benefit of others. I am currently on hemodialysis dialysis and have been for the past 3 years. I have also been on parataniel dialysis before receiving my transplant in 08. I have been so lost lately.. almost took my own life too. As soon as I read this I knew what I had to do and why I was here and have suffered what I have. I live in Edmonton alberta canada. You can reach me through doctor markland, or pisani from the royal alex or directly by using my email - [email protected].
Please get back to me. I'll do what ever I have to do to aid in this venture. Thanks. And to those struggling.. stay strong !

Cindy Loveless · Jul 23, 2019

My dad needs this kidney bad they sent him home last week said he cant do dialysis anymore PLEASE HELP HIM HE WILL DIE WITHOUT IT THEY GAVE HIM 2 WEEKS. Please get back to me, my email is [email protected]

Curious daughter · Jul 24, 2019

What about patients that are unable to make the transplant list? My step dad has been on hemo dialysis for 11yrs now due to polycystic kidneys, about 6yrs ago he lost both of his kidneys. The strain of this long term treatment has weakened his bones causing him to have to have both hips replaced.He has fought cancer 4 times now an will never be a candidate for the list. He would love nothing more than to come away from his machine an be able to travel for his grand babies and to have a more fulfilling life. But would this even be an option for someone like him or is he doomed to stay tied to a machine 5 days a week for the rest of his life?

N Woods · Jul 24, 2019

Very interested in being a participant in the kidney transplant. Been on dialysis for 2 years and diagnosed with end stage renal failure. My contact info is [email protected]

Jane Doe · Jul 25, 2019

I am stage 5 renal failure with no chance of a transplant because I have antibodies in my blood. I would love to be chosen for the trial.

Read more at: https://forum.facmedicine.com/threa...19-with-first-patient-implants-in-2020.41543/

Bj Howell · Jul 25, 2019

Being at Stage 5 I'd love to get one but I know insu companies and Big Pharma will never let the "common man" have one.

Erin Kerlin · Jul 25, 2019

Mahmoud Abudeif said: ↑

"The End Of An Era Of dialysis", this is the suitable title for this medical innovation, artificial kidneys will be ready for human trials at the end of 2019 with first implants in 2020 according to a recent update from the researches responsible for this project.

If approved by the FDA, the breakthrough creation could save thousands of patients currently on the transplant list for a new kidney.

The Kidney Project, which is the coalition heading the contraption’s development, published an update today saying that they have been asked to conduct additional preclinical testing before receiving approval for human trials.

“While the request for additional evidence was not anticipated, it is a measure of the revolutionary nature of our project that there is no precedent for safety reviews of similar technology and materials,” wrote the organization. “In that light, it is understandable that the research ethics boards are requesting additional data to document the safety of the bioartificial kidney.”

The project, which is headed by researchers from the University of California San Francisco (UCSF), the University of Vanderbilt, and the National Institute of Biomedical Imaging and Bioengineering (NIBIB), says that they are optimistic about receiving approval for the trials by late 2019.

The coalition first started causing buzz on the internet after they published their groundbreaking research back in February.

Creating an artificial implantable kidney would be an epic advance in medicine and could address a chronic shortage of donor kidneys needed for transplant. Researchers have been at this quest for the past 15 years and keep coming upon one extremely knotty problem: how to keep the blood flowing smoothly through the artificial device without clotting. In such devices, as blood platelets respond to mechanical forces, they have a natural tendency to clot, causing a device malfunction.

While dialysis saves thousands, if not millions, of lives each year, it is not an ideal solution for kidney disease. Instead of continuous blood filtration, which keeps blood chemistry within a healthy range, dialysis results in ultra-cleansed and nutrient-depleted blood, which becomes gradually more toxic until the following dialysis treatment.

An artificial kidney would provide the benefit of continuous blood filtration. It would reduce kidney disease illness and increase the quality of life for patients. While researchers have made progress on wearable models, to make the device implantable—driven by the body’s own blood flows—the clotting problem would need to be resolved.

The implantable artificial kidney—a bioengineered device that combines a high-efficiency silicon filter and a bioreactor of kidney tubule cells– is designed to accommodate up to a liter of blood per minute, filtering it through an array of silicon membranes. The filtered fluid contains toxins, water, electrolytes, and sugars. The fluid then undergoes a second stage of processing in a bioreactor of lab-grown cells of the type normally lining the tubules of the kidney. These cells reabsorb most of the sugars, salts, and water back into the bloodstream. The remainder becomes urine that is directed to the bladder and out of the body.

The researchers generated simulation and optimization results for two device designs that each channel blood through the artificial kidney filter system. Through simulation, they calculated that an individual platelet may flow through the artificial kidney as many as 1,000 times, accumulating stress and increasing the tendency to clot with each pass. One design distributes blood through parallel channels that pass across multiple layers of filtering membranes. The other channels blood back and forth through a single serpentine path.

Both designs met the researchers’ predetermined criteria for the uniform flow of blood through the devices and accumulation of shear stress forces on the platelets against the walls of the device flow channels.

The simulation approach has accelerated the project by saving on animal experimentation and offering a viable alternative to examine the pros and cons of different devices that contact blood. “To do that in animal studies is time consuming, expensive, and at some level you never know if it is going to work out—because animal blood is not the same as human blood,” said Shuvo Roy, one of the study’s co-authors.

Will the device have all the functions of a native kidney? “No,” Roy said. “But the goal is for it to perform the functions that are critical, and to be a device that, once implanted, will allow a patient to eat and drink freely, have mobility, better health overall, and unlike a transplant, not require immunosuppressant drugs.”

“We are hopeful that the first clinical trial will begin this year,” Roy told Snopes back in March. “If all goes well and funds are available, we could be on the market as early as 2020.”

The Kidney Project says that they have already received an abundance of applications for the human trials. Screenings will proceed once they receive approval from the board of ethics.

Source
Click to expand...

Please let me in on how to recieve the bionic kidney. I am a very hard match. My email is [email protected]. thank you

Trish Fox · Jul 26, 2019

My mom has only one kid eyes that is halfway working g. Unfortunately she is not a candidate for a kidney transplant due to calcium deposits. My question is, would she be a candidate for this??

Lamont Thompson · Jul 27, 2019

Mahmoud Abudeif said: ↑

"The End Of An Era Of dialysis", this is the suitable title for this medical innovation, artificial kidneys will be ready for human trials at the end of 2019 with first implants in 2020 according to a recent update from the researches responsible for this project.

If approved by the FDA, the breakthrough creation could save thousands of patients currently on the transplant list for a new kidney.

The Kidney Project, which is the coalition heading the contraption’s development, published an update today saying that they have been asked to conduct additional preclinical testing before receiving approval for human trials.

“While the request for additional evidence was not anticipated, it is a measure of the revolutionary nature of our project that there is no precedent for safety reviews of similar technology and materials,” wrote the organization. “In that light, it is understandable that the research ethics boards are requesting additional data to document the safety of the bioartificial kidney.”

The project, which is headed by researchers from the University of California San Francisco (UCSF), the University of Vanderbilt, and the National Institute of Biomedical Imaging and Bioengineering (NIBIB), says that they are optimistic about receiving approval for the trials by late 2019.

The coalition first started causing buzz on the internet after they published their groundbreaking research back in February.

Creating an artificial implantable kidney would be an epic advance in medicine and could address a chronic shortage of donor kidneys needed for transplant. Researchers have been at this quest for the past 15 years and keep coming upon one extremely knotty problem: how to keep the blood flowing smoothly through the artificial device without clotting. In such devices, as blood platelets respond to mechanical forces, they have a natural tendency to clot, causing a device malfunction.

While dialysis saves thousands, if not millions, of lives each year, it is not an ideal solution for kidney disease. Instead of continuous blood filtration, which keeps blood chemistry within a healthy range, dialysis results in ultra-cleansed and nutrient-depleted blood, which becomes gradually more toxic until the following dialysis treatment.

An artificial kidney would provide the benefit of continuous blood filtration. It would reduce kidney disease illness and increase the quality of life for patients. While researchers have made progress on wearable models, to make the device implantable—driven by the body’s own blood flows—the clotting problem would need to be resolved.

The implantable artificial kidney—a bioengineered device that combines a high-efficiency silicon filter and a bioreactor of kidney tubule cells– is designed to accommodate up to a liter of blood per minute, filtering it through an array of silicon membranes. The filtered fluid contains toxins, water, electrolytes, and sugars. The fluid then undergoes a second stage of processing in a bioreactor of lab-grown cells of the type normally lining the tubules of the kidney. These cells reabsorb most of the sugars, salts, and water back into the bloodstream. The remainder becomes urine that is directed to the bladder and out of the body.

The researchers generated simulation and optimization results for two device designs that each channel blood through the artificial kidney filter system. Through simulation, they calculated that an individual platelet may flow through the artificial kidney as many as 1,000 times, accumulating stress and increasing the tendency to clot with each pass. One design distributes blood through parallel channels that pass across multiple layers of filtering membranes. The other channels blood back and forth through a single serpentine path.

Both designs met the researchers’ predetermined criteria for the uniform flow of blood through the devices and accumulation of shear stress forces on the platelets against the walls of the device flow channels.

The simulation approach has accelerated the project by saving on animal experimentation and offering a viable alternative to examine the pros and cons of different devices that contact blood. “To do that in animal studies is time consuming, expensive, and at some level you never know if it is going to work out—because animal blood is not the same as human blood,” said Shuvo Roy, one of the study’s co-authors.

Will the device have all the functions of a native kidney? “No,” Roy said. “But the goal is for it to perform the functions that are critical, and to be a device that, once implanted, will allow a patient to eat and drink freely, have mobility, better health overall, and unlike a transplant, not require immunosuppressant drugs.”

“We are hopeful that the first clinical trial will begin this year,” Roy told Snopes back in March. “If all goes well and funds are available, we could be on the market as early as 2020.”

The Kidney Project says that they have already received an abundance of applications for the human trials. Screenings will proceed once they receive approval from the board of ethics.

Source
Click to expand...

I would like to do the trials as [email protected]

Naomi Johnson · Jul 27, 2019

Hello! I have an Aunt who just completed her second week of dialysis, which has come about as a complication of Type 2 Diabetes. How would one get more detailed information about becoming a study participant? Thank you much!

James Casberg · Jul 29, 2019

My name is James casberg, please add me to the list of candidates for the trials I am a 33 yr old male in Fresno California I have been on dialysis for 5 years. Thank you. [email protected]

Mahmoud Abudeif · Aug 1, 2019

Could you please check out this post: https://forum.facmedicine.com/threa...frequently-asked-questions-by-patients.42451/
it has all the information you need to know and the official form for clinical trials.

Heather Semones said: ↑

So do it now, lets make history. My son is on dialysis awaiting a transplant at 12 years old. Had his cath put in today and dialysis starts soon. Lost his kidneys to a rare autoimmune wegenera disease.
Click to expand...

Jacquelyn Dale said: ↑

How can I apply for a chance of getting a bionic kidney. Very interested in this project. Thanks, Jacquelyn Dale
[email protected]
Click to expand...

Leadie Speights said: ↑

Please contact [email protected]
Click to expand...

Jeffery Overturf said: ↑

I lost my left Kidney to clear cell cancer. My right Kidney has chronic Kidney disease. Please help me. 469-235-2477. [email protected].
Click to expand...

Janet Elton said: ↑

My name is Janet Elton and I have stage 4 kidney failure and am on the kidney transplant list. I have a viable fistula in case my kidneys shut down. I am very interested in getting a bionic kidney. I am open to any clinical trials as well.
Click to expand...

Janet Elton said: ↑

My name is Janet Elton and I have stage 4 kidney failure and am on the kidney transplant list. I have a viable fistula in case my kidneys shut down. I am very interested in getting a bionic kidney. I am open to any clinical trials as well.
Click to expand...

Jennifer O'Connor said: ↑

I am wondering if you're still taking candidates for a bionic kidney ??
Thanks, -jen
Click to expand...

Eduardo Francis said: ↑

Hi I am a 46 year old man from baton rouge, La. I have agressive pkd and I am very interested in possibly participating in the clinical trials of the bionic kidney. My kidney function is at about 25 percent. So I am stage 4 renal. Please contact me if at all possible. Thank you.
Click to expand...

JSteuer said: ↑

My husband discovered he had a congenital defect of being born with only one kidney when his only kidney failed. Due to aggressive, non-malignant tumors he had that kidney removed. He is not being considered for a transplant. I have been doing his hemodialysis at home for three years. Please. We jave three children who have been watching their father die befor them for 3.5 years.
Click to expand...

Mr Timothy said: ↑

Bs Bs Bs Bs.. They've beend saying theor going to start clinical trials for years .. literally. Don't believe the BS. Their just out to sell you a dream and take your money.
Click to expand...

Ethan Montgonery said: ↑

Please contact me as I am more than willing to put my life on the line for the future benefit of others. I am currently on hemodialysis dialysis and have been for the past 3 years. I have also been on parataniel dialysis before receiving my transplant in 08. I have been so lost lately.. almost took my own life too. As soon as I read this I knew what I had to do and why I was here and have suffered what I have. I live in Edmonton alberta canada. You can reach me through doctor markland, or pisani from the royal alex or directly by using my email - [email protected].
Please get back to me. I'll do what ever I have to do to aid in this venture. Thanks. And to those struggling.. stay strong !
Click to expand...

Cindy Loveless said: ↑

My dad needs this kidney bad they sent him home last week said he cant do dialysis anymore PLEASE HELP HIM HE WILL DIE WITHOUT IT THEY GAVE HIM 2 WEEKS. Please get back to me, my email is [email protected]
Click to expand...

Curious daughter said: ↑

What about patients that are unable to make the transplant list? My step dad has been on hemo dialysis for 11yrs now due to polycystic kidneys, about 6yrs ago he lost both of his kidneys. The strain of this long term treatment has weakened his bones causing him to have to have both hips replaced.He has fought cancer 4 times now an will never be a candidate for the list. He would love nothing more than to come away from his machine an be able to travel for his grand babies and to have a more fulfilling life. But would this even be an option for someone like him or is he doomed to stay tied to a machine 5 days a week for the rest of his life?
Click to expand...

N Woods said: ↑

Very interested in being a participant in the kidney transplant. Been on dialysis for 2 years and diagnosed with end stage renal failure. My contact info is [email protected]
Click to expand...

Jane Doe said: ↑

I am stage 5 renal failure with no chance of a transplant because I have antibodies in my blood. I would love to be chosen for the trial.

Read more at: https://forum.facmedicine.com/threa...19-with-first-patient-implants-in-2020.41543/
Click to expand...

Trish Fox said: ↑

My mom has only one kid eyes that is halfway working g. Unfortunately she is not a candidate for a kidney transplant due to calcium deposits. My question is, would she be a candidate for this??
Click to expand...

Lamont Thompson said: ↑

I would like to do the trials as [email protected]
Click to expand...

Naomi Johnson said: ↑

Hello! I have an Aunt who just completed her second week of dialysis, which has come about as a complication of Type 2 Diabetes. How would one get more detailed information about becoming a study participant? Thank you much!
Click to expand...

James Casberg said: ↑

My name is James casberg, please add me to the list of candidates for the trials I am a 33 yr old male in Fresno California I have been on dialysis for 5 years. Thank you. [email protected]
Click to expand...

Moe Abulohoum · Aug 8, 2019

How can I apply for a chance of getting a bionic kidney. Very interested in this project.

Read more at: https://forum.facmedicine.com/threa...19-with-first-patient-implants-in-2020.41543/

Moe Abulohoum · Aug 8, 2019

Angela Blake said: ↑

My husband has been on dialysis for 17 years. He is currently 52 years old. He is very much interested in participating in the trial phase. How does he go about getting an application?
Click to expand...

How can I apply for a chance of getting a bionic kidney. Very interested in this project.

Read more at: https://forum.facmedicine.com/threa...19-with-first-patient-implants-in-2020.41543/

Milovan Jelcic · Sep 26, 2019

I am impressed with your research and efforts and I do hope you will start with implementation of bionic kidney as soon as possible.
My name is Milovan Jelčić ,I am male,62,from Serbia ,and I would like to participate in your program of transportation of bionic kidney asap, including my covering the whole costs and expenses .
Thank you in advance .
My email is [email protected] phone number is +38163500023.
Best regards,
Milovan Jelčić, PhD of Law

Efrain Otero · Jan 15, 2020

JSteuer said: ↑

My husband discovered he had a congenital defect of being born with only one kidney when his only kidney failed. Due to aggressive, non-malignant tumors he had that kidney removed. He is not being considered for a transplant. I have been doing his hemodialysis at home for three years. Please. We jave three children who have been watching their father die befor them for 3.5 years.
Click to expand...

Mahmoud Abudeif said: ↑

"The End Of An Era Of dialysis", this is the suitable title for this medical innovation, artificial kidneys will be ready for human trials at the end of 2019 with first implants in 2020 according to a recent update from the researches responsible for this project.

If approved by the FDA, the breakthrough creation could save thousands of patients currently on the transplant list for a new kidney.

The Kidney Project, which is the coalition heading the contraption’s development, published an update today saying that they have been asked to conduct additional preclinical testing before receiving approval for human trials.

“While the request for additional evidence was not anticipated, it is a measure of the revolutionary nature of our project that there is no precedent for safety reviews of similar technology and materials,” wrote the organization. “In that light, it is understandable that the research ethics boards are requesting additional data to document the safety of the bioartificial kidney.”

The project, which is headed by researchers from the University of California San Francisco (UCSF), the University of Vanderbilt, and the National Institute of Biomedical Imaging and Bioengineering (NIBIB), says that they are optimistic about receiving approval for the trials by late 2019.

The coalition first started causing buzz on the internet after they published their groundbreaking research back in February.

Creating an artificial implantable kidney would be an epic advance in medicine and could address a chronic shortage of donor kidneys needed for transplant. Researchers have been at this quest for the past 15 years and keep coming upon one extremely knotty problem: how to keep the blood flowing smoothly through the artificial device without clotting. In such devices, as blood platelets respond to mechanical forces, they have a natural tendency to clot, causing a device malfunction.

While dialysis saves thousands, if not millions, of lives each year, it is not an ideal solution for kidney disease. Instead of continuous blood filtration, which keeps blood chemistry within a healthy range, dialysis results in ultra-cleansed and nutrient-depleted blood, which becomes gradually more toxic until the following dialysis treatment.

An artificial kidney would provide the benefit of continuous blood filtration. It would reduce kidney disease illness and increase the quality of life for patients. While researchers have made progress on wearable models, to make the device implantable—driven by the body’s own blood flows—the clotting problem would need to be resolved.

The implantable artificial kidney—a bioengineered device that combines a high-efficiency silicon filter and a bioreactor of kidney tubule cells– is designed to accommodate up to a liter of blood per minute, filtering it through an array of silicon membranes. The filtered fluid contains toxins, water, electrolytes, and sugars. The fluid then undergoes a second stage of processing in a bioreactor of lab-grown cells of the type normally lining the tubules of the kidney. These cells reabsorb most of the sugars, salts, and water back into the bloodstream. The remainder becomes urine that is directed to the bladder and out of the body.

The researchers generated simulation and optimization results for two device designs that each channel blood through the artificial kidney filter system. Through simulation, they calculated that an individual platelet may flow through the artificial kidney as many as 1,000 times, accumulating stress and increasing the tendency to clot with each pass. One design distributes blood through parallel channels that pass across multiple layers of filtering membranes. The other channels blood back and forth through a single serpentine path.

Both designs met the researchers’ predetermined criteria for the uniform flow of blood through the devices and accumulation of shear stress forces on the platelets against the walls of the device flow channels.

The simulation approach has accelerated the project by saving on animal experimentation and offering a viable alternative to examine the pros and cons of different devices that contact blood. “To do that in animal studies is time consuming, expensive, and at some level you never know if it is going to work out—because animal blood is not the same as human blood,” said Shuvo Roy, one of the study’s co-authors.

Will the device have all the functions of a native kidney? “No,” Roy said. “But the goal is for it to perform the functions that are critical, and to be a device that, once implanted, will allow a patient to eat and drink freely, have mobility, better health overall, and unlike a transplant, not require immunosuppressant drugs.”

“We are hopeful that the first clinical trial will begin this year,” Roy told Snopes back in March. “If all goes well and funds are available, we could be on the market as early as 2020.”

The Kidney Project says that they have already received an abundance of applications for the human trials. Screenings will proceed once they receive approval from the board of ethics.

Source
Click to expand...

How can I apply to receive one?

Mr Timothy · Jan 16, 2020

Listen folks.. They have been saying this for 5 years now.. Clinical trials next year.. ITS ALL BS... Ive email these people asking to see the data on animal testing and clearance.. Got nothing.. I really wish they would stop giving people false hope.. Just like with type 1 diabetes.. They keep saying will have a cure within 5 years.. Well its been 25 years since Ive heard that statement and here we are.. No cure.. No closer.. I'm not trying to burst anyone's bubble.. I just feel the truth is far far better than a pipe dream or a drawing on a cocktail napkin.. Stay healthy.. Find a donor..

Steven Grunstein · Feb 3, 2020

Looks like your on schedule for FDA approval this is good news. So I have PKD. Will the tubules cells from my right kidney work? Or is there something else that can be done to make this work for me? I'm 58 and pretty active and healthy. And how will I know when this bionic kidney is approved? How much wait time do you anticipate for Medicare patients
will have to wait? And what sort of things will disqualify one from receving one?

Steven Grunstein · Jun 17, 2020

Hello I was wondering how this was moving along? Is it still on track for trials or is it already in human trials? I relise living in Alaska im not gonna be in the front of the line but i havent heard anything since last summer. Need more cash run an article in AMAC its fir sr citezens. You wont need to ask for money just say it is pending x amount ill bet folks will donate. Anyway I would love to know where this is at at this time.
Thank you
Steven Grunstein
Ps I have at least 5 or 6 family members with PKD and one with dialisys due to diabedes.

dorseyjulius · Oct 31, 2020

on Saturday, i was denied a transplant a third time, at this point im looking at other options and wanted to know how to sign up as a volunteer for this

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Human Trials For Artificial Kidney To Begin At The End of 2019, With First Patient Implants In 2020

Ethan Montgonery Active member

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Erin Kerlin Young Member

Trish Fox Young Member

Lamont Thompson Young Member

Naomi Johnson Young Member

James Casberg Young Member

Mahmoud Abudeif Golden Member

Moe Abulohoum Young Member

Moe Abulohoum Young Member

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Human Trials For Artificial Kidney To Begin At The End of 2019, With First Patient Implants In 2020

Ethan Montgonery Active member

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Curious daughter Young Member

N Woods Young Member

Jane Doe Young Member

Bj Howell Well-Known Member

Erin Kerlin Young Member

Trish Fox Young Member

Lamont Thompson Young Member

Naomi Johnson Young Member

James Casberg Young Member

Mahmoud Abudeif Golden Member

Moe Abulohoum Young Member

Moe Abulohoum Young Member

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